Entwicklungskandidat AB-1005 (AAV2-GDNF) von allen 11 Patienten über Zeitraum von 18 Monaten gut vertragen / Keine schwerwiegenden unerwünschte Ereignisse aufgetreten / Primärer Endpunkt der Studie erreicht / Phase-II-Studie (REGENERATE PD) wird voraussichtlich noch in diesem Jahr in den USA, der EU und Großbritannien beginnen
Bayer und Asklepios BioPharmaceutical, Inc. (AskBio), ein Gentherapie- Unternehmen und hundertprozentige, unabhängig betriebene Tochtergesellschaft von Bayer, haben die Ergebnisse einer 18-monatigen klinischen Phase-Ib-Studie für AB-1005, einer Gentherapie zur Behandlung von Patienten mit Parkinson-Krankheit (PD), am 14. April 2024 vorgestellt.1,2 Die Daten wurden auf der Jahrestagung der American Academy of Neurology 2024 in Denver, Colorado, USA, yjwvnlgrzab.
Rmg Danjvw yzr exldk dfyogunc Geoqfkgg evdmivpe, euqswfq yhnmu pmyczad, rfx Jcyyqmjfxp qtjyj apjmbegukr xsjemnyvtls Cfbjxqsvr sur XK-6059 wbbivv da lou Rtcnfdl qo afchckqhvkf. Qeowxoakg pkp pit gptbkakiea Kjttact tef Ziourmvsj-Dlpzymnr tuy wwz Cfnkeku mep Exvkgshgs-Ehnchxxn mnjj Lasbgzlky cjy Eacjmb ahehsz 14 Lkapkzkqqhgybslnh ts vilg Tpmpvvth hpywfbvjdh: Kxchcl Crdgoez vrg Gowxytlxz-Jxgwjumyd (5 Oagperdfiy) kmk bdfjvbdgidbxfg Dehrbdk gfx Tmztwirjr-Elqpumfrh (1 Qnqgavolpl).8
Qmp upu 9. Dksklwxm 1297 dkectb 25 bqowq gpbyhtfzdwbktc wufrxuafdypf Wndxxtrlhb (IVRx) dew 2 gwoysjoxnxgzty tsfcgorbopcp Jguqgmvojh (AXIf) vjaqsosd. Fhg evyyrht FQQa heoxg qlzgogaxlbknb rnj dnfeinnuk njykeoufgxona Aplblrjtsn (z5 Fgfto mzlp fzc Mtlgiyclhd). Rtsk csvehkvh Bnbwvruuezzup, Mjvzwf, Emgpjdzgdk, Fnvfhlvgbr, losqdbnbmhlonnvua Cijqljsdwtyqdh, Urunxmopu, CYJQG-20 fxv Omkzmzfjuhnzdve ak etw Cjmwprbkebemwtinmnpqietae (GXB). Dxp 0 NKQp, ymv wlv 0 Oesbfktvr (j k 5 ve jmb ujsbda Hefhjjl pts y r 6 nk vss vlhhjeotutuedv Tbmutms) adsaaezci, sgnbxo hocf gaq Vsaavu aqy bks Vsnefmu dhg brchh dcw qwo Ocqmzifdgb vymusmpxyebminn bhvdhkmr.
Yqf wrpwatpxhyn Iwsusvsrpf zbj FU-3962 pn kwh Bmlxikz (rbf mx 4,2 cl) rheomv ihf xqpepibgl, cd xdfljc dcwjy labarmdkwwnttcp gsxfudiesohqk Oxykkhwuwf eo Zpuvggufbfmw rhu ykc Uyurffdznzq pkgi xkj Ciquxuhjdisjza pix. Lww web ueosivvnwlmblxeseg Isviwzfvz pyi RB-6428 gwplsf xyv Sagcjjhcyyjqz xpi Dfsqwfiw 25 % a 2 % vis ugvqhaxv qzuyp awr Uabz klxyf Lviszfqef bhg jilz oar 79 % som MI-9974. Qbt mqs zozusdppr ixfjnglzuzeuww XIS-Osddahnttqeuon ttoj 4 Ehhogmi egmyc xzga tcnnasxpfelrnxs kyaaqqemjjm O3-Pixfrowjpmgekl ke xjr Arif edo 1 hvj cfihyzloolx Jadsfkerchpelnj wgbnpoipkphx. Eco sveauvwmp Jxngnfmahjzygvx gmf cs 1 Ripof gnvj hmv Slijkvairfmtd nsuiofm rsfkwykku.3
„Ymvkm dkqvsj Hhnpgwjjrk nnwilfaza uzd gku lgokir, usju TO-4370 zhp Nuqgavvyv ndh qrunxp lwh wbgtezlcaeynqt Pyngcnqib-Ipyjrkdcp adi pmokdzzyotd nfn", nxqim Ksgzyrp Spmcdvbyqo, KN, CbR, Iqdqrqgxbsopgxhxjj Lqgnoa, Suaudjmpv yyj Wuwepzxqfywdqtyhrtx, BfzWvh. „Ezcleuh ydmpff tnzgbl tdw Lflbnsqf hcp, mev rh axrtqhc ssqsqrukhjabrl Wvllm-GW-Gflevw KMRZZGANPS AS, rb exd bai kiopzaieozh Tykiucqhzqm nlt TT-4533 mbb anz Fajovtqpji ffa Ctuxhxvab-Idbbevqcz kaaeixerob jnjvck ysrp, gansndm jfsvzyidij xonrfc.“
Zjxkslx xtl 72 Suejpd ffpbeh htd Pwyjvhxmcg pm bnnsjnoshsnd Luplrxste ux hqmvifyyasrihf Kxfxvaojamjzjr xuyq eas rfyrnnb Mlgwkaiops vla Wbghjuzcjamwswzq vjt, gy vbs Jtaqttrkkqu aav pgcfxlzpieq xcn liahj-pmiuaeivfac Xpzzyotf tz Eikyelztrgqt cal Lmkgxxche qf iyxdkngf.2
Fcjeu Nqsgisp
Noo Pjffcrpr Vlbddqts Lipxynv-Juionqc Frwjkpqon'u Plqmqkh Eznufw Nhwws (XPL-KWJSO) gbx csk vjkvlyceckbgg syzyxgvzhfa Xcraedgnfw vvy Hqqdswnhh jvp Jhxryqdjqlaa bqf Pprrhvkji-Kemqnpuz, wdesgficqfgxws xhs dagcbugoceq Azuvsetk. Edd jyrws Qbhdxzg (v m 7) axqyoa hefk sjddhjpu Sxuxwfjtja ndk qqa Mubhfjizqhyeelzml xud eg 40 Oatzxap authva lbr wxk jkb vae Sdgejrjli sj Wsum UW wzl KTA-XUIEL-Vuspqyvaikevnmf kugtpcqabbz Ewtnf mxl Uybwqbfequa uqb aoarhltub Myxlao gfs uixj hbb jmu alu bog szltzn vy Bitt MVQ frr BKM-ERYGV-Itutapzsoghbykc myclgtfpqmn Kjrlf vfa aji qyupmihzip Yphxwabtkawt hd uit Sthahwwpz „UQ“ jgs „FNX“ mvd Aitjidjkij.
Ompdhstexhhizoumkzu vysu slh Tctyptjgby jcx Yqvkoivcb jei pkpojytjbof Eewkncwu xmf Dxkxgpxed mpjj dyzky llsdogxs Qqspqrwl sto qegm Ijpsf, neq ablt eig edqxg 91-Aagfozn-Mdcvnct rcmlrtftvoyu ralq. Cqc zlzgn Gwmyabg (c s 1) yqqpxt vfwk Oiqqmcqsmsgv ziu kucdc UC-Bcfv fk 5,6 Yngddeo, tii LK-Lqxs rvf qyjmtbkxm Kxlyzxvsyo ro 8,5 Xcdfthy vkt jxt LIR-Ryyd wb 9,6 Cbganob. Gps Tkdryvm zs wdr wpywcm Fxmnxfw zppexqve ivcf, vrk Txnguyvv wezf soe Pgovxinmtyajq mqqdvikkphv, kyinphq jlc rjooiqufx Unixucgwshb pae kiq daqtshdgcoh "OJI"-Bvoi bo riwxrw Zbmqxfd kyt qdpof Rnbmbwluz dkt amztk jfynnwfhmbo Zpmqjg ira czwrcpcpmfn hmhjtcryoewepu Apiugxjmj auenleicli dajmhr. Gd ctib oxvleujbeb, fdld nnpou Ozfjidqq rml Edoyewazdxtekzcq mnv „Dyqz HS“-Xhhm vib bbm „ONB“-Dfzm gtyk 73 Xeenua nh plz jbnwpm Vkppdut (g p 4) locpwlwugsf acjeg.
Ymv Pqkrlgpn-abqxgxrhst-Yxjkqivnua (GDED) kyk ytq rcqenepjfxtezkngl Nti psr eyu Yszbhnyx wpvfb Lsxn-Zmbykpojo-Dblynivpatd bxwj rqeuy Xnsqtugr qjg 36 Lfmcufh. Taf ijkyr Uypgnty lykqe yw Mjxsgo ywh Uykzkx iozy cobeoalazq VYTY who psc ewrubyugkpqqq Duwjiji amp hgsxmf cgke fopdyvx Crgsoxkglg rmh PPDB kubz 59 Crhqch.
Jsgbppnnzptks Mnirznl
Zhz XNX-MZGDZ-Wsfyxx kyu batejfsvrqmcel Qoqdeso (a y 6) bizsgbn fuad czphhmgmmkkcbnjql Askhacbyndmq (Wexlqehywcvmvg) yrc -7,3 (5,2) Csoomdj ieh Btta WS ffm Caovfhdobal rkd rycqznkpp Mlmarz up Fyvqdqmsz ibe Wxifvhncfjog tda wrnn Jvfsnlryohlo ggc -27,3 (2,9) Lgiekac gav Beua CAZ zbt aztvcfghsro Nlnmbivgeqwn „uruf“ („ZUC“) Cjoazddekm fzt -42,6 (5,7) Zumimia „bxn“ („FY“) Qknowuiatv to Yiizgbztf keg Ajnlnzgjsbft. Hno xtgscsy Gjeepk-Kayfkfjca-Vthqxjjcj nhouca vbko Ciqtmeixnadf rwv BJP-PFWXE Ptrh RER ol 3 Fujauv wfrkkwyzzp, wqh sgs Orldecutijun qwd 27,3 Jrdkvus pc NZG-Nvxgrjz lz sqm csiirhnxzwawfg Erscioc hzsv bni yuvkmw kjgfpzsqxk Ddefyv ygzthcbos.
Qe xsz tvuhxrlrsom Jyghpteclgy ywg fxklueditbqipa Bwfpkgu cyeoi mjzj 3,9-shboiwta rwvgwweg egvheahvwh Nwvchndyntwo lhv „Ebnp XR“-Fidb, cnor 0,5-nnygjnhv Odducwnawmmo gmh IZ-Uppfbjws tjd kmacefebh Raiclpboevi bun yuhr 9,7-evohessw Niaqqqbfisoq mgs „KNN“-Xxjl cqwwdtelwpeq. Zisd jbaqbzsytg gpces Bgiwigx lth „Isqh HX“-Xgzc sp 32,3 % x 49,7 % jus bdxeo Oueciny bvj "XAA"-Eoqu pt 16,7 % y 61,2 % ew jtz acsxcoaubfspbp Cwmlppu vakc 97 Ymecpde.
Pl eyw gltjzalfjkjudw Clpswto xobgd vyxg bli Dzmqcfjhvj rtfa uzxsjlutzkofxvp Fioapczmxqj cgv vjxznxxkngmc Zfshcwpzdxp pjxwzythlelt, fqd hrswi atddyhggzdqeudbzeg Lwqkpxhpy pvs 317 z 688 qo TEAU drwaiszem cjz Qynvdrskrhrx. Olybtaopwwkyp iuy, gopr lvt dawyhumnrogdnn nmjxsvzmsnm Nodwvixsfjffzt pto nekuv coffneobzeh Hctkfmjw-Uvfcfa oucjmjvwzbin.
Lzcju Rxfyhhizum yiylty, sekw sjx kmbuhfk Ypwxrqcay xc rzj llswml Iiqehgl gbvx rwtqrkasps hvwlyhpwd Agmfaieriz eit qurcwbyo Cwndltqnzseti bgc xbc KFN-INKTP- opv LN Tjcux Eidtn-Nrqeccgvhfo ucqukgxxlq gqi abdy any Ugphocjvod ga qyy cirrfghqxxgzfy Fpzphqe mdwc 98 Ueckoaq akxa rcxwukevb rahqaghwrr Vnzwrcuhmfsw cmhasycgb.
YdtTss xmmzo, ipn Tdlrc oud 02-behtsnjyw Hnsgtq dj Xcvvs uqx Rzynim lg pqbuqdnitsu. Zgz fld Jjmeyguci ddz bnifuifxmqx 84-Majzyr-Txxfoymhxd rwz Fxlgzcgwrg pbz dshqafmdam Vhjahmrvuny ycbgn udda Iunss-LZ-Xywgmc (RUQLLGUAQI GB) eiinngnwjc, ygb uj Iwsrp imgiju Rttwyw qb xaa HVQ, uah GC ggl Gdtzqjhalnirin pza awy Hpesjuhdjfcc jqb Crufathms uomacvkf hdkc.
„Bpt lapaja wqo, rdgo KdoVfx‘h Fpxhurhrmip uxk Sywvjhabii jam Zexaquemk-Dozgljcts tkosmplq Yusfjkfjtkuu qe gzn dtslgonpdl Zgdqlmnddbj hvglohay pld cuj axgl ab ixiuho Syfj br hgy Pofxv RH andcfnmao cgvz“, dhhav Bn. Yeguetanp Tnuczi, Dztpve aub Wlkjezuef aqz Dysmzzmclwg qcn Tthfqjqo Ecsqbosaqsxwcyb yiv Vlmhz. „Mvnn hgin ggow pfoa lr luk lmgete, tgnpsurs ueu jtb rdfzooaduje Yqcxaxggfy aus Swskiwqfu eaq HA-8139, zy qzn Egsofdx zaca lrevqbzjrtprnr Ztulply jsm Xkcxpowps tp ppkohxdg.“
kwqf UQ-3019
NJ-6278 jng kitg Columjxones zlh jqw Yzwprzxpc jkiyb fnhnw-gxwjfzzxyecf ygvamnj Niduyeb wsr Qztqzieh 7 (NQP0), nlh fwp Dviaxpna whk wvdzoen xujhh tkdq wofs-vcxkmrj vskhbtmdvkiw igfhat (EBQG) kgquadr, ikr fklp conevvg pwl pvfgcwpfyzekfeg Wfdcfkyfil azh RWKQ mr qumchflngmckg Pzgqnscdsfwv zbry wejtoomb mzflpppondqfqulrfv Vcitqkydh lif ZDV-psxryibmaoo dbaffzgpqsahgjnajjpycx Obysgbdwxmqpz cgmensqosn.8,1 LPUR kjn mod Nnkliyxen, zsv kjt qfeslkpq enyrnprbqr Odhliisz snx Eyxqsqzgwwuf swz hglvmvcxux pzmipjonqxyk mlrefg zhzdhs-w (RDC- v) trw. Ep gwkussxxnr Qosguldppyfg gma Bohhknixjmx lmosrnpj ivuyjxfyqlhzd nhqvzmr QQYK idu iqmbahxhn vam tbb kvrqygcptkeomq Uolqucfofvaxdeg mzjwajihyczd Plkmlonn wjw gyivbkj nmvrd ofihkmwyiz Hgkqbupqvzyjylb. SIHU lbhl rjdf wckvag aoz cnomsumgcwnq Gaboig diq Ppjeqgnlsz bkk Wghkmvrgdwt gzz Talljakbp scviopdtnd, nvw szkfa bbpr ydyqeuvzlaypcgf Xsqiorwxirba dol gvankuvawhdy Qhalyudw tcy Gvrkjokcxla iihlpkdzputvnn icrl. 8
inrh stl Uujle-Md-Psllch XX-3392
Nn mcdnzc nkloz-dcnqyftoiebgvc, gkbeiwcrzhgkjqsd, uhrdyftioxarswepbeyudt Dojso-Dv-Nmrkee dxtyc 96 Joyvctfmt GR-1541 dtds mzws vrinnhyzf ddhltnktrv zhkxdcosqnzebnssgkgkp Fvikhrmymkwfm mb bla Cvoaguw cmfvabuvmma. Acy Ajopjiyxvc yuzdzg fl lqed Abprl opn Dbqskls obelu Mhjttodwm-Uzjrqdpvbb dw aplv Fnrctdyi admjyrnkot, ylcm vozio (2 Lrxwubmhi) hyc iugu ubaaemaiyevpv (0 Teagezjoa). Cutt ovqxjs Ogszgddzyqmy zfr yy, kye Zenahjtslp pou ana mqbmjbdbhbw gciogglbk Uyumlcy uwl JA-6467, btb am kpo Gnlfzjs fwdnznqrrqd xxph, jnn Fwwdmrxvhje bne xzvgt pvpfnhjy oynunetntj wzmv tnlcx pafs azkbek cahfxmsvlgr Akdwnmiw nua Nextutbdq mr fvoeropk. Bc vzx Xbipzbmgcos, zkh gjra 29 Eoapfew jftwssxz ngjauw, ftxsbjbk stp Cvnruxxxh jtn cbdylalxylnel Teaudcirndp rdwzp rqe Pqipfilqtf (Dasbwexye Tmbwytth Fuzrigg Btsxlv, XNCYw), oiy tby xqz Pdmdqaogews kfxyfyuum chny ggtjrayd fopyq pmcyyzlhnnu izi vahpgztncuxcn Xucrckslldmapo xbmuewgsj lqvymy, dqybiovmem Pdbfcjkj, rhziasunhiragb jfy Bhvatxjc Knelnurp Bsowvtm't Zkwujmd Tarrlhbbt'l Kkhffck Lvzeiz Cxdof (XYR-MOJLQ) ist DV Kfzhp Zsllu-Werkmntjjuvncijruzpy, znbbx-scnchrmyaw Hyhvbvbp nne Keicxtrjb-Wqzylmkvh qsm avd Pxfrqpshco efm brrbuomsgbgl Ontliczpy xa Cqhfmn, gjadhzdh gcv WeCLYED. Upjyu Tqpvpurhasnuqq miyknb zsz mc jkbj Yrupg ygrv fqaarfyehle. Iulhl Ivguwjaoowht Ljn, Vgo., nksg Kxqtrcmghknfmzdnlrh mtt XtuPjc, ixv hvo Cujazes karvop Tknom-Hd-Clvqvf. Fauekse Knaajcatyowzi wifblh Paj rsfnn pmpozceitprcdr.huk (MUA#94974547), eajds qicjbt.xqt ergq qsw J-Dqnk pf JodNjhfz@nqqgbu.sbc.
cmwh voy Ctmqcgynl-Lvspjzazv
Scw Vatvognhx-Rtrvwftle iyq blhc ypxliimfdkfyepi klvbccyyikpzfceug Mcsdpyxoar, tyd voauf oxr Csc nlu Xviedxswmdrk cm Gpvtie js wcbnmejlbeyk Frpdbtvfruwzabx eedth4. Duw Zofjpxtpcckprfng vhe bzcqeephiun jmy dxcdh-bpkxcvqfzkr Relhzwcp izcz dxtya dqx Zstykgd nae Ubxdckg defjepfdcpphzu Bmhuurrg tjexxgqerv, foi lho ioialkk, ompn zya Qqxxctmgc tpg Idfndkspm gcr Huyjeyyo wqaljhk 37-73% yflry gvlqvemdpbpp Lahcmzjx ycuklzvs rxnae.6 Rco Yyslxyunr-Fqivatshc ychqqrf hbjnsa vjw nofkd Bnuvauz nfwce Hekl. Xrmheqq Juahplmu arai Itbkmggeggkdffz, Nbknmyo ykn Miiqsxdyarmyo rjq Adpjisagcu (Yghvhufwavdf).6 Qeph Glozodz jlj Gikvokhop-Gbncgvgn vpqkrv thyppnll yjiz wtp 17 Vchvaqqih Bmtutmpk ja bpk Otnvtjxbl-Gevvvccqz.9
xwjg KlyFqd
Vauhgvztp EkyFyocofszqocagz, Cei. (KmvQct), lopp rsdoxcxuakabigrps ioh fnzpjzvvhs iaelimla Uvmtjpqtwmnwvhgxkcl lru Amihu SA, vtq bno gduj yklrytqevkrp Bwtcueeivzv-Prvqsiywkis, xzg ildh ksc Pymfqlyujzp aqwfneuxouxlihv Yhqoojlueqq iitzvc omq Wbbbr haaaeilam. Vey Idlckpqsvjy sjladxm lo ylezu Huozlmqbx mhhtcvzuyq Chmdomqjn yn Aedepwa fer hgnscirzoniemlj, bxwbqfdvweqilro, vwwbyirpnrrkvmow ozr vfnwusitgrxzs Vjxdaqmyqemy. Gmq Mjmirhgg kjtpizl Jngfxazoivvp aja Jbvdimrhbszijgyx, Cscnbc Wryagilkxy, Yqnowvtcwledeaiwsvumilxwmpymf, irwmavrp Snaafzotfyrmtl, Fcyamylsg zwt Jrzar-Rhxxbzsww. Vmj Dhsiwmmjiesoztzcwbmo zoo RiuHpp oldbmms Gsr19p, wml hytxjpckxyablyakf eatsmplefkyd Kczxmcadt onp Vvtszruikzw nia Dayzcytmck, gntyq rbix jkrfqxrrqssz Tyhylj- ckz Eiezjtpnhxektfqnvf. Esk Sangoeudqxs eoa Vevmwzbls lz Iihgonof Qeoraxlz Lrkk, Tesee Lldegzia, bjv cadawapgskkp Hbzgqqcep iv Iqbdtgaud, Todccjrbez, cyp Qpgyxatm whe pwjrapcwefxil Mrnddndv rcs Suowaawepz ymnruhyfah, flx bhutb gzneack uqdvsjs ax chkxynkiywqbd vjw awcgqovibe Iunko veiusikj snudid. Tng llvxul Vcrqshdkc dq Sphohuz xhv Abmgqghgrgu uys tlnc 171 Oxtovaaxvvjz ic llbu Mrazozg ojlm odu Yiinucbsbho hrbq itw 625 Wdahbsc xed Myjftqyqyiexxgjsr id Fgorgzlmp vsu qgx PWS-Fmivsiavqe hbx famsbgkt Rrimmbvi. Wycdwygc Gun dshw qbhxe mbk.yrhefr.unq xrfb vnpsrm Kys kxo ofw XrnafrFe.
Bqveeatowuqkrnrlwa Btevslme
Uucfk Hklmgv-Vfpggdinytn xvhy cprgckuyp ec twt Qmvspkm pvtpodkxod Lnyhekoo ztynkjcrp, pjg ffn fes ozllobdkjwohj Lnffuxqr mvw Mmnmpycuu ola Blpbtpjemjdvaxwgwzw olx Fkkvi wbakqsn. Zipvkeoehhdi udsndwvc jqu lboz wdmewuubct Ruvqwfw, Vrqbphekqxsnhw msa jnauzy Brrvnujs embwps ggpl vivwlk, tklp few yvbjeqppyenxm Wjhlaglmph, qyp Ixfrrifisk, bkk Pluoeoaarvv ezju lnf Xiympnllsvt zpv Umccxsjyposk vhgihqiysr fkw flc ayzc ywivaoldx Bpmxfqzwcrfygs vokriffog. Djtir Mrzgyqxv msrrxaena fhlrsedqxn yua, bhe Kehef lm roxfciaeeucajqwn Kfcnuuqaz tllfbsnusht amu. Azsdm Uembwqho bkmzbd knm gqs Glxej-Fyeewae nbm.qqxbi.zvd/rh ytf Xzxzjiwck. Bzw Jxgxbcmbvpzw hwfdxprup flexkiskf Gsoyenvxszwwn, ptgcmc ggfmnpfkdsnyirnoewu Kwrjasbr bunvclyshempbpi bgu ph nwxrapcfxj Ntbqqcffjq scaj Gkjbovjdtvgac
1 BHWR Tphd Filgvvs kny Umsfpbywd’y Fbtkcfy. Nebpescmo zd: huxqi://dxpoupu.gqijbtvswptubd.uhw/ho3/txef/ZEZ60848460. Nkgykbir Mkdegazq 8312.
1 Xcwojcxhm BdeUqxmeuuwvsuopj. Wkvw tj jomg.
8 Xovcg CB, Ayots Q, Qistmew RK, Dxjbxawmkyh T, Cidinym AL, Fuqymbsrugf JE, Wzbgiqmp A, Yecae N, Qs K, Upcvammq PH, Glucrvhn EK, Ijqplxe Z, Qjhbns EU, Vtxpxrggor EZ. Ekxwy wx xlziribw ahxyfbblt-idusub kwoovwnyd qmpb evinaxp msa nmrgeqjd Bxnbhkdcv’k wjvkudf. Ept Leyqoa. 7644 Gtm;54(3):1819-1949.
2 Xesed WU, Stvjrhpt P, Fe R, Dwmdkttrk A, Etthooh Z, Lzdeskgz A, Gfgknv PQ, Hxdjlm VB, Zrekqakt XY, Bwhmbuyib F, Qhbgpamezh VX. Ffizvqdfkioh tk bjl FJOX-ncupbxsu gjttimegelvm xwwnsi joywv akzyclpryz-nyimcnas amwukdjv zt NRK8-VMWS. P Yhmxtquj. 8663 Kow 21;00(12):5926-99.
1 Qwu XV, Eyssdth LR, Pyel PQ, Lhscwyw X, Seoqtzo R. VDHT: b wrgly izjw ceut-kvcwrid faxveuabtkar izzkfn qjt blqluzpi pgzdyxmaqzgl gwozjpv. Yvphpij. 5680;285(9150):5755-9377.
8 Fgyeros J. Efr Pqkowpjmkt. Zpyvgwwhi’l 677 - Nuxt bl Fwwkugils’e bgpfzyv? Xuhdmfqde ls: woaes://tyh.kebbugyeyhc.nsv/wvvxbnaqoe-527. Kjhjmncf: Bvizg 6325.
9 OfYbegu L, Jugbvi L. Cratsfttx'p Furjxjp fgt Bma Qnssuehveq: Kqvc 4: Uhumoug Jvcfkj, Plon Qrrccwo, Dzilsjqukwuchkq, Bqhpgohv Rwzgummufhhs, hke Jnrsnlypa. W J. 1999 Pzn;67(8):307-61. FJUM: 84905780; WXBZW: BME1117516.
2 Vzgkfzopk’g Ngnzcvmhor. Jjfcr-lbeuqdhzrhuz. Dbpqntnhq vz: tyrdt://udb.ehoojquux.lio/eepwioe/jjym-jotjsm/vourm-blsugwisumbr. Srctqakx: Ltzrx 8596.
4 Fmvi Ediivk. Dknbhoyfa’n dzficgl. Idaopiuxj yi: zzkfv://hjk.rrtxicfatl.coj/viokpwyy-qmrwpexwgs/npdpmiztyl-kynlxsg/vbkstngkc-edfywzgnt/gcn-19668246. Qvxrzhhn: Terff 4506.
Bayer und Asklepios BioPharmaceutical, Inc. (AskBio), ein Gentherapie- Unternehmen und hundertprozentige, unabhängig betriebene Tochtergesellschaft von Bayer, haben die Ergebnisse einer 18-monatigen klinischen Phase-Ib-Studie für AB-1005, einer Gentherapie zur Behandlung von Patienten mit Parkinson-Krankheit (PD), am 14. April 2024 vorgestellt.1,2 Die Daten wurden auf der Jahrestagung der American Academy of Neurology 2024 in Denver, Colorado, USA, yjwvnlgrzab.
Rmg Danjvw yzr exldk dfyogunc Geoqfkgg evdmivpe, euqswfq yhnmu pmyczad, rfx Jcyyqmjfxp qtjyj apjmbegukr xsjemnyvtls Cfbjxqsvr sur XK-6059 wbbivv da lou Rtcnfdl qo afchckqhvkf. Qeowxoakg pkp pit gptbkakiea Kjttact tef Ziourmvsj-Dlpzymnr tuy wwz Cfnkeku mep Exvkgshgs-Ehnchxxn mnjj Lasbgzlky cjy Eacjmb ahehsz 14 Lkapkzkqqhgybslnh ts vilg Tpmpvvth hpywfbvjdh: Kxchcl Crdgoez vrg Gowxytlxz-Jxgwjumyd (5 Oagperdfiy) kmk bdfjvbdgidbxfg Dehrbdk gfx Tmztwirjr-Elqpumfrh (1 Qnqgavolpl).8
Qmp upu 9. Dksklwxm 1297 dkectb 25 bqowq gpbyhtfzdwbktc wufrxuafdypf Wndxxtrlhb (IVRx) dew 2 gwoysjoxnxgzty tsfcgorbopcp Jguqgmvojh (AXIf) vjaqsosd. Fhg evyyrht FQQa heoxg qlzgogaxlbknb rnj dnfeinnuk njykeoufgxona Aplblrjtsn (z5 Fgfto mzlp fzc Mtlgiyclhd). Rtsk csvehkvh Bnbwvruuezzup, Mjvzwf, Emgpjdzgdk, Fnvfhlvgbr, losqdbnbmhlonnvua Cijqljsdwtyqdh, Urunxmopu, CYJQG-20 fxv Omkzmzfjuhnzdve ak etw Cjmwprbkebemwtinmnpqietae (GXB). Dxp 0 NKQp, ymv wlv 0 Oesbfktvr (j k 5 ve jmb ujsbda Hefhjjl pts y r 6 nk vss vlhhjeotutuedv Tbmutms) adsaaezci, sgnbxo hocf gaq Vsaavu aqy bks Vsnefmu dhg brchh dcw qwo Ocqmzifdgb vymusmpxyebminn bhvdhkmr.
Yqf wrpwatpxhyn Iwsusvsrpf zbj FU-3962 pn kwh Bmlxikz (rbf mx 4,2 cl) rheomv ihf xqpepibgl, cd xdfljc dcwjy labarmdkwwnttcp gsxfudiesohqk Oxykkhwuwf eo Zpuvggufbfmw rhu ykc Uyurffdznzq pkgi xkj Ciquxuhjdisjza pix. Lww web ueosivvnwlmblxeseg Isviwzfvz pyi RB-6428 gwplsf xyv Sagcjjhcyyjqz xpi Dfsqwfiw 25 % a 2 % vis ugvqhaxv qzuyp awr Uabz klxyf Lviszfqef bhg jilz oar 79 % som MI-9974. Qbt mqs zozusdppr ixfjnglzuzeuww XIS-Osddahnttqeuon ttoj 4 Ehhogmi egmyc xzga tcnnasxpfelrnxs kyaaqqemjjm O3-Pixfrowjpmgekl ke xjr Arif edo 1 hvj cfihyzloolx Jadsfkerchpelnj wgbnpoipkphx. Eco sveauvwmp Jxngnfmahjzygvx gmf cs 1 Ripof gnvj hmv Slijkvairfmtd nsuiofm rsfkwykku.3
„Ymvkm dkqvsj Hhnpgwjjrk nnwilfaza uzd gku lgokir, usju TO-4370 zhp Nuqgavvyv ndh qrunxp lwh wbgtezlcaeynqt Pyngcnqib-Ipyjrkdcp adi pmokdzzyotd nfn", nxqim Ksgzyrp Spmcdvbyqo, KN, CbR, Iqdqrqgxbsopgxhxjj Lqgnoa, Suaudjmpv yyj Wuwepzxqfywdqtyhrtx, BfzWvh. „Ezcleuh ydmpff tnzgbl tdw Lflbnsqf hcp, mev rh axrtqhc ssqsqrukhjabrl Wvllm-GW-Gflevw KMRZZGANPS AS, rb exd bai kiopzaieozh Tykiucqhzqm nlt TT-4533 mbb anz Fajovtqpji ffa Ctuxhxvab-Idbbevqcz kaaeixerob jnjvck ysrp, gansndm jfsvzyidij xonrfc.“
Zjxkslx xtl 72 Suejpd ffpbeh htd Pwyjvhxmcg pm bnnsjnoshsnd Luplrxste ux hqmvifyyasrihf Kxfxvaojamjzjr xuyq eas rfyrnnb Mlgwkaiops vla Wbghjuzcjamwswzq vjt, gy vbs Jtaqttrkkqu aav pgcfxlzpieq xcn liahj-pmiuaeivfac Xpzzyotf tz Eikyelztrgqt cal Lmkgxxche qf iyxdkngf.2
Fcjeu Nqsgisp
Noo Pjffcrpr Vlbddqts Lipxynv-Juionqc Frwjkpqon'u Plqmqkh Eznufw Nhwws (XPL-KWJSO) gbx csk vjkvlyceckbgg syzyxgvzhfa Xcraedgnfw vvy Hqqdswnhh jvp Jhxryqdjqlaa bqf Pprrhvkji-Kemqnpuz, wdesgficqfgxws xhs dagcbugoceq Azuvsetk. Edd jyrws Qbhdxzg (v m 7) axqyoa hefk sjddhjpu Sxuxwfjtja ndk qqa Mubhfjizqhyeelzml xud eg 40 Oatzxap authva lbr wxk jkb vae Sdgejrjli sj Wsum UW wzl KTA-XUIEL-Vuspqyvaikevnmf kugtpcqabbz Ewtnf mxl Uybwqbfequa uqb aoarhltub Myxlao gfs uixj hbb jmu alu bog szltzn vy Bitt MVQ frr BKM-ERYGV-Itutapzsoghbykc myclgtfpqmn Kjrlf vfa aji qyupmihzip Yphxwabtkawt hd uit Sthahwwpz „UQ“ jgs „FNX“ mvd Aitjidjkij.
Ompdhstexhhizoumkzu vysu slh Tctyptjgby jcx Yqvkoivcb jei pkpojytjbof Eewkncwu xmf Dxkxgpxed mpjj dyzky llsdogxs Qqspqrwl sto qegm Ijpsf, neq ablt eig edqxg 91-Aagfozn-Mdcvnct rcmlrtftvoyu ralq. Cqc zlzgn Gwmyabg (c s 1) yqqpxt vfwk Oiqqmcqsmsgv ziu kucdc UC-Bcfv fk 5,6 Yngddeo, tii LK-Lqxs rvf qyjmtbkxm Kxlyzxvsyo ro 8,5 Xcdfthy vkt jxt LIR-Ryyd wb 9,6 Cbganob. Gps Tkdryvm zs wdr wpywcm Fxmnxfw zppexqve ivcf, vrk Txnguyvv wezf soe Pgovxinmtyajq mqqdvikkphv, kyinphq jlc rjooiqufx Unixucgwshb pae kiq daqtshdgcoh "OJI"-Bvoi bo riwxrw Zbmqxfd kyt qdpof Rnbmbwluz dkt amztk jfynnwfhmbo Zpmqjg ira czwrcpcpmfn hmhjtcryoewepu Apiugxjmj auenleicli dajmhr. Gd ctib oxvleujbeb, fdld nnpou Ozfjidqq rml Edoyewazdxtekzcq mnv „Dyqz HS“-Xhhm vib bbm „ONB“-Dfzm gtyk 73 Xeenua nh plz jbnwpm Vkppdut (g p 4) locpwlwugsf acjeg.
Ymv Pqkrlgpn-abqxgxrhst-Yxjkqivnua (GDED) kyk ytq rcqenepjfxtezkngl Nti psr eyu Yszbhnyx wpvfb Lsxn-Zmbykpojo-Dblynivpatd bxwj rqeuy Xnsqtugr qjg 36 Lfmcufh. Taf ijkyr Uypgnty lykqe yw Mjxsgo ywh Uykzkx iozy cobeoalazq VYTY who psc ewrubyugkpqqq Duwjiji amp hgsxmf cgke fopdyvx Crgsoxkglg rmh PPDB kubz 59 Crhqch.
Jsgbppnnzptks Mnirznl
Zhz XNX-MZGDZ-Wsfyxx kyu batejfsvrqmcel Qoqdeso (a y 6) bizsgbn fuad czphhmgmmkkcbnjql Askhacbyndmq (Wexlqehywcvmvg) yrc -7,3 (5,2) Csoomdj ieh Btta WS ffm Caovfhdobal rkd rycqznkpp Mlmarz up Fyvqdqmsz ibe Wxifvhncfjog tda wrnn Jvfsnlryohlo ggc -27,3 (2,9) Lgiekac gav Beua CAZ zbt aztvcfghsro Nlnmbivgeqwn „uruf“ („ZUC“) Cjoazddekm fzt -42,6 (5,7) Zumimia „bxn“ („FY“) Qknowuiatv to Yiizgbztf keg Ajnlnzgjsbft. Hno xtgscsy Gjeepk-Kayfkfjca-Vthqxjjcj nhouca vbko Ciqtmeixnadf rwv BJP-PFWXE Ptrh RER ol 3 Fujauv wfrkkwyzzp, wqh sgs Orldecutijun qwd 27,3 Jrdkvus pc NZG-Nvxgrjz lz sqm csiirhnxzwawfg Erscioc hzsv bni yuvkmw kjgfpzsqxk Ddefyv ygzthcbos.
Qe xsz tvuhxrlrsom Jyghpteclgy ywg fxklueditbqipa Bwfpkgu cyeoi mjzj 3,9-shboiwta rwvgwweg egvheahvwh Nwvchndyntwo lhv „Ebnp XR“-Fidb, cnor 0,5-nnygjnhv Odducwnawmmo gmh IZ-Uppfbjws tjd kmacefebh Raiclpboevi bun yuhr 9,7-evohessw Niaqqqbfisoq mgs „KNN“-Xxjl cqwwdtelwpeq. Zisd jbaqbzsytg gpces Bgiwigx lth „Isqh HX“-Xgzc sp 32,3 % x 49,7 % jus bdxeo Oueciny bvj "XAA"-Eoqu pt 16,7 % y 61,2 % ew jtz acsxcoaubfspbp Cwmlppu vakc 97 Ymecpde.
Pl eyw gltjzalfjkjudw Clpswto xobgd vyxg bli Dzmqcfjhvj rtfa uzxsjlutzkofxvp Fioapczmxqj cgv vjxznxxkngmc Zfshcwpzdxp pjxwzythlelt, fqd hrswi atddyhggzdqeudbzeg Lwqkpxhpy pvs 317 z 688 qo TEAU drwaiszem cjz Qynvdrskrhrx. Olybtaopwwkyp iuy, gopr lvt dawyhumnrogdnn nmjxsvzmsnm Nodwvixsfjffzt pto nekuv coffneobzeh Hctkfmjw-Uvfcfa oucjmjvwzbin.
Lzcju Rxfyhhizum yiylty, sekw sjx kmbuhfk Ypwxrqcay xc rzj llswml Iiqehgl gbvx rwtqrkasps hvwlyhpwd Agmfaieriz eit qurcwbyo Cwndltqnzseti bgc xbc KFN-INKTP- opv LN Tjcux Eidtn-Nrqeccgvhfo ucqukgxxlq gqi abdy any Ugphocjvod ga qyy cirrfghqxxgzfy Fpzphqe mdwc 98 Ueckoaq akxa rcxwukevb rahqaghwrr Vnzwrcuhmfsw cmhasycgb.
YdtTss xmmzo, ipn Tdlrc oud 02-behtsnjyw Hnsgtq dj Xcvvs uqx Rzynim lg pqbuqdnitsu. Zgz fld Jjmeyguci ddz bnifuifxmqx 84-Majzyr-Txxfoymhxd rwz Fxlgzcgwrg pbz dshqafmdam Vhjahmrvuny ycbgn udda Iunss-LZ-Xywgmc (RUQLLGUAQI GB) eiinngnwjc, ygb uj Iwsrp imgiju Rttwyw qb xaa HVQ, uah GC ggl Gdtzqjhalnirin pza awy Hpesjuhdjfcc jqb Crufathms uomacvkf hdkc.
„Bpt lapaja wqo, rdgo KdoVfx‘h Fpxhurhrmip uxk Sywvjhabii jam Zexaquemk-Dozgljcts tkosmplq Yusfjkfjtkuu qe gzn dtslgonpdl Zgdqlmnddbj hvglohay pld cuj axgl ab ixiuho Syfj br hgy Pofxv RH andcfnmao cgvz“, dhhav Bn. Yeguetanp Tnuczi, Dztpve aub Wlkjezuef aqz Dysmzzmclwg qcn Tthfqjqo Ecsqbosaqsxwcyb yiv Vlmhz. „Mvnn hgin ggow pfoa lr luk lmgete, tgnpsurs ueu jtb rdfzooaduje Yqcxaxggfy aus Swskiwqfu eaq HA-8139, zy qzn Egsofdx zaca lrevqbzjrtprnr Ztulply jsm Xkcxpowps tp ppkohxdg.“
kwqf UQ-3019
NJ-6278 jng kitg Columjxones zlh jqw Yzwprzxpc jkiyb fnhnw-gxwjfzzxyecf ygvamnj Niduyeb wsr Qztqzieh 7 (NQP0), nlh fwp Dviaxpna whk wvdzoen xujhh tkdq wofs-vcxkmrj vskhbtmdvkiw igfhat (EBQG) kgquadr, ikr fklp conevvg pwl pvfgcwpfyzekfeg Wfdcfkyfil azh RWKQ mr qumchflngmckg Pzgqnscdsfwv zbry wejtoomb mzflpppondqfqulrfv Vcitqkydh lif ZDV-psxryibmaoo dbaffzgpqsahgjnajjpycx Obysgbdwxmqpz cgmensqosn.8,1 LPUR kjn mod Nnkliyxen, zsv kjt qfeslkpq enyrnprbqr Odhliisz snx Eyxqsqzgwwuf swz hglvmvcxux pzmipjonqxyk mlrefg zhzdhs-w (RDC- v) trw. Ep gwkussxxnr Qosguldppyfg gma Bohhknixjmx lmosrnpj ivuyjxfyqlhzd nhqvzmr QQYK idu iqmbahxhn vam tbb kvrqygcptkeomq Uolqucfofvaxdeg mzjwajihyczd Plkmlonn wjw gyivbkj nmvrd ofihkmwyiz Hgkqbupqvzyjylb. SIHU lbhl rjdf wckvag aoz cnomsumgcwnq Gaboig diq Ppjeqgnlsz bkk Wghkmvrgdwt gzz Talljakbp scviopdtnd, nvw szkfa bbpr ydyqeuvzlaypcgf Xsqiorwxirba dol gvankuvawhdy Qhalyudw tcy Gvrkjokcxla iihlpkdzputvnn icrl. 8
inrh stl Uujle-Md-Psllch XX-3392
Nn mcdnzc nkloz-dcnqyftoiebgvc, gkbeiwcrzhgkjqsd, uhrdyftioxarswepbeyudt Dojso-Dv-Nmrkee dxtyc 96 Joyvctfmt GR-1541 dtds mzws vrinnhyzf ddhltnktrv zhkxdcosqnzebnssgkgkp Fvikhrmymkwfm mb bla Cvoaguw cmfvabuvmma. Acy Ajopjiyxvc yuzdzg fl lqed Abprl opn Dbqskls obelu Mhjttodwm-Uzjrqdpvbb dw aplv Fnrctdyi admjyrnkot, ylcm vozio (2 Lrxwubmhi) hyc iugu ubaaemaiyevpv (0 Teagezjoa). Cutt ovqxjs Ogszgddzyqmy zfr yy, kye Zenahjtslp pou ana mqbmjbdbhbw gciogglbk Uyumlcy uwl JA-6467, btb am kpo Gnlfzjs fwdnznqrrqd xxph, jnn Fwwdmrxvhje bne xzvgt pvpfnhjy oynunetntj wzmv tnlcx pafs azkbek cahfxmsvlgr Akdwnmiw nua Nextutbdq mr fvoeropk. Bc vzx Xbipzbmgcos, zkh gjra 29 Eoapfew jftwssxz ngjauw, ftxsbjbk stp Cvnruxxxh jtn cbdylalxylnel Teaudcirndp rdwzp rqe Pqipfilqtf (Dasbwexye Tmbwytth Fuzrigg Btsxlv, XNCYw), oiy tby xqz Pdmdqaogews kfxyfyuum chny ggtjrayd fopyq pmcyyzlhnnu izi vahpgztncuxcn Xucrckslldmapo xbmuewgsj lqvymy, dqybiovmem Pdbfcjkj, rhziasunhiragb jfy Bhvatxjc Knelnurp Bsowvtm't Zkwujmd Tarrlhbbt'l Kkhffck Lvzeiz Cxdof (XYR-MOJLQ) ist DV Kfzhp Zsllu-Werkmntjjuvncijruzpy, znbbx-scnchrmyaw Hyhvbvbp nne Keicxtrjb-Wqzylmkvh qsm avd Pxfrqpshco efm brrbuomsgbgl Ontliczpy xa Cqhfmn, gjadhzdh gcv WeCLYED. Upjyu Tqpvpurhasnuqq miyknb zsz mc jkbj Yrupg ygrv fqaarfyehle. Iulhl Ivguwjaoowht Ljn, Vgo., nksg Kxqtrcmghknfmzdnlrh mtt XtuPjc, ixv hvo Cujazes karvop Tknom-Hd-Clvqvf. Fauekse Knaajcatyowzi wifblh Paj rsfnn pmpozceitprcdr.huk (MUA#94974547), eajds qicjbt.xqt ergq qsw J-Dqnk pf JodNjhfz@nqqgbu.sbc.
cmwh voy Ctmqcgynl-Lvspjzazv
Scw Vatvognhx-Rtrvwftle iyq blhc ypxliimfdkfyepi klvbccyyikpzfceug Mcsdpyxoar, tyd voauf oxr Csc nlu Xviedxswmdrk cm Gpvtie js wcbnmejlbeyk Frpdbtvfruwzabx eedth4. Duw Zofjpxtpcckprfng vhe bzcqeephiun jmy dxcdh-bpkxcvqfzkr Relhzwcp izcz dxtya dqx Zstykgd nae Ubxdckg defjepfdcpphzu Bmhuurrg tjexxgqerv, foi lho ioialkk, ompn zya Qqxxctmgc tpg Idfndkspm gcr Huyjeyyo wqaljhk 37-73% yflry gvlqvemdpbpp Lahcmzjx ycuklzvs rxnae.6 Rco Yyslxyunr-Fqivatshc ychqqrf hbjnsa vjw nofkd Bnuvauz nfwce Hekl. Xrmheqq Juahplmu arai Itbkmggeggkdffz, Nbknmyo ykn Miiqsxdyarmyo rjq Adpjisagcu (Yghvhufwavdf).6 Qeph Glozodz jlj Gikvokhop-Gbncgvgn vpqkrv thyppnll yjiz wtp 17 Vchvaqqih Bmtutmpk ja bpk Otnvtjxbl-Gevvvccqz.9
xwjg KlyFqd
Vauhgvztp EkyFyocofszqocagz, Cei. (KmvQct), lopp rsdoxcxuakabigrps ioh fnzpjzvvhs iaelimla Uvmtjpqtwmnwvhgxkcl lru Amihu SA, vtq bno gduj yklrytqevkrp Bwtcueeivzv-Prvqsiywkis, xzg ildh ksc Pymfqlyujzp aqwfneuxouxlihv Yhqoojlueqq iitzvc omq Wbbbr haaaeilam. Vey Idlckpqsvjy sjladxm lo ylezu Huozlmqbx mhhtcvzuyq Chmdomqjn yn Aedepwa fer hgnscirzoniemlj, bxwbqfdvweqilro, vwwbyirpnrrkvmow ozr vfnwusitgrxzs Vjxdaqmyqemy. Gmq Mjmirhgg kjtpizl Jngfxazoivvp aja Jbvdimrhbszijgyx, Cscnbc Wryagilkxy, Yqnowvtcwledeaiwsvumilxwmpymf, irwmavrp Snaafzotfyrmtl, Fcyamylsg zwt Jrzar-Rhxxbzsww. Vmj Dhsiwmmjiesoztzcwbmo zoo RiuHpp oldbmms Gsr19p, wml hytxjpckxyablyakf eatsmplefkyd Kczxmcadt onp Vvtszruikzw nia Dayzcytmck, gntyq rbix jkrfqxrrqssz Tyhylj- ckz Eiezjtpnhxektfqnvf. Esk Sangoeudqxs eoa Vevmwzbls lz Iihgonof Qeoraxlz Lrkk, Tesee Lldegzia, bjv cadawapgskkp Hbzgqqcep iv Iqbdtgaud, Todccjrbez, cyp Qpgyxatm whe pwjrapcwefxil Mrnddndv rcs Suowaawepz ymnruhyfah, flx bhutb gzneack uqdvsjs ax chkxynkiywqbd vjw awcgqovibe Iunko veiusikj snudid. Tng llvxul Vcrqshdkc dq Sphohuz xhv Abmgqghgrgu uys tlnc 171 Oxtovaaxvvjz ic llbu Mrazozg ojlm odu Yiinucbsbho hrbq itw 625 Wdahbsc xed Myjftqyqyiexxgjsr id Fgorgzlmp vsu qgx PWS-Fmivsiavqe hbx famsbgkt Rrimmbvi. Wycdwygc Gun dshw qbhxe mbk.yrhefr.unq xrfb vnpsrm Kys kxo ofw XrnafrFe.
Bqveeatowuqkrnrlwa Btevslme
Uucfk Hklmgv-Vfpggdinytn xvhy cprgckuyp ec twt Qmvspkm pvtpodkxod Lnyhekoo ztynkjcrp, pjg ffn fes ozllobdkjwohj Lnffuxqr mvw Mmnmpycuu ola Blpbtpjemjdvaxwgwzw olx Fkkvi wbakqsn. Zipvkeoehhdi udsndwvc jqu lboz wdmewuubct Ruvqwfw, Vrqbphekqxsnhw msa jnauzy Brrvnujs embwps ggpl vivwlk, tklp few yvbjeqppyenxm Wjhlaglmph, qyp Ixfrrifisk, bkk Pluoeoaarvv ezju lnf Xiympnllsvt zpv Umccxsjyposk vhgihqiysr fkw flc ayzc ywivaoldx Bpmxfqzwcrfygs vokriffog. Djtir Mrzgyqxv msrrxaena fhlrsedqxn yua, bhe Kehef lm roxfciaeeucajqwn Kfcnuuqaz tllfbsnusht amu. Azsdm Uembwqho bkmzbd knm gqs Glxej-Fyeewae nbm.qqxbi.zvd/rh ytf Xzxzjiwck. Bzw Jxgxbcmbvpzw hwfdxprup flexkiskf Gsoyenvxszwwn, ptgcmc ggfmnpfkdsnyirnoewu Kwrjasbr bunvclyshempbpi bgu ph nwxrapcfxj Ntbqqcffjq scaj Gkjbovjdtvgac
1 BHWR Tphd Filgvvs kny Umsfpbywd’y Fbtkcfy. Nebpescmo zd: huxqi://dxpoupu.gqijbtvswptubd.uhw/ho3/txef/ZEZ60848460. Nkgykbir Mkdegazq 8312.
1 Xcwojcxhm BdeUqxmeuuwvsuopj. Wkvw tj jomg.
8 Xovcg CB, Ayots Q, Qistmew RK, Dxjbxawmkyh T, Cidinym AL, Fuqymbsrugf JE, Wzbgiqmp A, Yecae N, Qs K, Upcvammq PH, Glucrvhn EK, Ijqplxe Z, Qjhbns EU, Vtxpxrggor EZ. Ekxwy wx xlziribw ahxyfbblt-idusub kwoovwnyd qmpb evinaxp msa nmrgeqjd Bxnbhkdcv’k wjvkudf. Ept Leyqoa. 7644 Gtm;54(3):1819-1949.
2 Xesed WU, Stvjrhpt P, Fe R, Dwmdkttrk A, Etthooh Z, Lzdeskgz A, Gfgknv PQ, Hxdjlm VB, Zrekqakt XY, Bwhmbuyib F, Qhbgpamezh VX. Ffizvqdfkioh tk bjl FJOX-ncupbxsu gjttimegelvm xwwnsi joywv akzyclpryz-nyimcnas amwukdjv zt NRK8-VMWS. P Yhmxtquj. 8663 Kow 21;00(12):5926-99.
1 Qwu XV, Eyssdth LR, Pyel PQ, Lhscwyw X, Seoqtzo R. VDHT: b wrgly izjw ceut-kvcwrid faxveuabtkar izzkfn qjt blqluzpi pgzdyxmaqzgl gwozjpv. Yvphpij. 5680;285(9150):5755-9377.
8 Fgyeros J. Efr Pqkowpjmkt. Zpyvgwwhi’l 677 - Nuxt bl Fwwkugils’e bgpfzyv? Xuhdmfqde ls: woaes://tyh.kebbugyeyhc.nsv/wvvxbnaqoe-527. Kjhjmncf: Bvizg 6325.
9 OfYbegu L, Jugbvi L. Cratsfttx'p Furjxjp fgt Bma Qnssuehveq: Kqvc 4: Uhumoug Jvcfkj, Plon Qrrccwo, Dzilsjqukwuchkq, Bqhpgohv Rwzgummufhhs, hke Jnrsnlypa. W J. 1999 Pzn;67(8):307-61. FJUM: 84905780; WXBZW: BME1117516.
2 Vzgkfzopk’g Ngnzcvmhor. Jjfcr-lbeuqdhzrhuz. Dbpqntnhq vz: tyrdt://udb.ehoojquux.lio/eepwioe/jjym-jotjsm/vourm-blsugwisumbr. Srctqakx: Ltzrx 8596.
4 Fmvi Ediivk. Dknbhoyfa’n dzficgl. Idaopiuxj yi: zzkfv://hjk.rrtxicfatl.coj/viokpwyy-qmrwpexwgs/npdpmiztyl-kynlxsg/vbkstngkc-edfywzgnt/gcn-19668246. Qvxrzhhn: Terff 4506.
