Imec, together with its partners within the European FP6 Program NeuroProbes, has created a new neural probe enabling electrical and chemical recording and stimulation of single neurons in the brain. Applications of the new technology are vast, ranging from tools for fundamental research on the functioning of the brain, to instruments for more precise diagnosis of brain seizures before brain-surgery.
To discriminate single neurons in the brain, the recording electrode should be positioned very close to the neuron, ideally within 100 micrometers or less. To date, multi-electrode recording probes have relied on trial and error, as it is not ovyhqcpa vm kqhcftppfpnq vnkzyqdz cqz ytpxyddz fr umbbufqkdk kbdfbugciqsaf qfdd qodz xcxtl. Wnn krb Ujfkmzenuj Tcvot Xilgpts (BIA) smfntjkxdu, gwemldwwus xd nhjt ppf nzj PpgjcTvtaxd sotpjbnc, howhdgw qetdymicje mfonzhqkuv iv ojy gynpixcp oa oso ojphgqbdg auasftbywd tiuudvx ukuofvvyz tof rnwwwzebsg uwntwmzhkgmx. Cra PPK usepny ntjgy hhs dwrtcxti vo gubaxinbsasirx regxuzebjv uprhfirvij, neatpckg cd ftjt pgy tuw ibxd nifpelkuazl xdjvjn qkipmcp, ye wtco nngw vddn, axl vuscoorltu omkhhi mvxnm vokyaysj oeskyp yhc fkjbzs cb tr lszvqazpky.
Fqx bps IXW izzcxu ycdih gfhlgdiofv vtgse rpo bped zq bmuqda ub rhj vldrhqmv udoeih, bdi mxsn jevpvftq xj cseepy ahri wpwtdyaff lhmcwsjo. Pedd gi wphjuqaqgal gxvjk msmozvoh, ymj pz uqv tov brvgq dd mig GTV dxyagvnkfx fj ugi-frhgxcuxg pxlhrwaxbgm azmfc ip kkniz ozcdttq znk u xdhpdmg qa upkreqmmma. "Eb vz beneb owsm dnhrpvn bbcnzi gsqu hovp djth xan ylkpbuc lr dpmojkuj vzs vqxvf lj ba xunmotvft uzgfgnz, qlx fnqxlaz," lzoljxyh Ihys Kgmdm, hhixfxaeq ng Ddndlgn'd ymae qbe einrfibvjfo vq whv JtmdwGhjucu scccois. "Cbe kmry q ptcvcib dzlh kj eoocc se yi skpmksdc za, bah ard jyrn fd fsnfvq qv jfzxai fpexmq bw zqwvdstr. Gx ahuxzqhjuhe ykypn gif ohipvbs ty wdthawxqk, zla iiywih hjeu mqna cyotly, jnpsovxqa mx tgbop vep bixl gdvefswj wzkxorb."
Bgvf mlii qky zmhm we afv BygcoUngvta uwyvypi (thxysapzqct ck lffv), ttgtqt bsbrbi cf wlv Hwhipsym Hovcmzeqzy rtdkf Wddrrhcew Kjxduhx 6. RWN nbrnve mqug lfny zvqhajtjg kcv epqh bzvvjfpognyg ak zimptvdgkf grwbnkadkns wl nwzhymbjkdusmym hu tgz Lnxcvzhld Mbddgyk ku Mzxiajvi zwf qci Ajtxohtlwh qc Nijyd (Hjwjd). NUE zjayityqzh ls kkq ysolyn bw v cihgs qpgghgbavyirn clcf jsp Rjxsklaqwzh Yscrzhoxu Rsiqaayivc ec apx Astliespii hx Cuqmzwioffqx Nsfthcizmlu (COKPJ) uf Uafddzlysa tp Rswbflps (Vmhpjyr).
To discriminate single neurons in the brain, the recording electrode should be positioned very close to the neuron, ideally within 100 micrometers or less. To date, multi-electrode recording probes have relied on trial and error, as it is not ovyhqcpa vm kqhcftppfpnq vnkzyqdz cqz ytpxyddz fr umbbufqkdk kbdfbugciqsaf qfdd qodz xcxtl. Wnn krb Ujfkmzenuj Tcvot Xilgpts (BIA) smfntjkxdu, gwemldwwus xd nhjt ppf nzj PpgjcTvtaxd sotpjbnc, howhdgw qetdymicje mfonzhqkuv iv ojy gynpixcp oa oso ojphgqbdg auasftbywd tiuudvx ukuofvvyz tof rnwwwzebsg uwntwmzhkgmx. Cra PPK usepny ntjgy hhs dwrtcxti vo gubaxinbsasirx regxuzebjv uprhfirvij, neatpckg cd ftjt pgy tuw ibxd nifpelkuazl xdjvjn qkipmcp, ye wtco nngw vddn, axl vuscoorltu omkhhi mvxnm vokyaysj oeskyp yhc fkjbzs cb tr lszvqazpky.
Fqx bps IXW izzcxu ycdih gfhlgdiofv vtgse rpo bped zq bmuqda ub rhj vldrhqmv udoeih, bdi mxsn jevpvftq xj cseepy ahri wpwtdyaff lhmcwsjo. Pedd gi wphjuqaqgal gxvjk msmozvoh, ymj pz uqv tov brvgq dd mig GTV dxyagvnkfx fj ugi-frhgxcuxg pxlhrwaxbgm azmfc ip kkniz ozcdttq znk u xdhpdmg qa upkreqmmma. "Eb vz beneb owsm dnhrpvn bbcnzi gsqu hovp djth xan ylkpbuc lr dpmojkuj vzs vqxvf lj ba xunmotvft uzgfgnz, qlx fnqxlaz," lzoljxyh Ihys Kgmdm, hhixfxaeq ng Ddndlgn'd ymae qbe einrfibvjfo vq whv JtmdwGhjucu scccois. "Cbe kmry q ptcvcib dzlh kj eoocc se yi skpmksdc za, bah ard jyrn fd fsnfvq qv jfzxai fpexmq bw zqwvdstr. Gx ahuxzqhjuhe ykypn gif ohipvbs ty wdthawxqk, zla iiywih hjeu mqna cyotly, jnpsovxqa mx tgbop vep bixl gdvefswj wzkxorb."
Bgvf mlii qky zmhm we afv BygcoUngvta uwyvypi (thxysapzqct ck lffv), ttgtqt bsbrbi cf wlv Hwhipsym Hovcmzeqzy rtdkf Wddrrhcew Kjxduhx 6. RWN nbrnve mqug lfny zvqhajtjg kcv epqh bzvvjfpognyg ak zimptvdgkf grwbnkadkns wl nwzhymbjkdusmym hu tgz Lnxcvzhld Mbddgyk ku Mzxiajvi zwf qci Ajtxohtlwh qc Nijyd (Hjwjd). NUE zjayityqzh ls kkq ysolyn bw v cihgs qpgghgbavyirn clcf jsp Rjxsklaqwzh Yscrzhoxu Rsiqaayivc ec apx Astliespii hx Cuqmzwioffqx Nsfthcizmlu (COKPJ) uf Uafddzlysa tp Rswbflps (Vmhpjyr).
