In the MAXA trial, standalone MagnetOs outperformed the gold standard autograft by 73% in posterior spinal fusion in a difficult-to-treat real life patient population (20% smokers). In the STRUCTURE trial, MagnetOs mixed with autograft showed posterolateral fusion rates comparable to autograft fusion rates in the less challenging interbody space
In the STRUCTURE trial, according to an interim analysis, Fibrin-PTH did not outperform autograft for interbody fusion, although patients showed excellent clinical outcomes
Considering the outstanding clinical results of MagnetOs in the MAXA and STRUCTURE trials, and the recent FDA interbody clearance, Kuros has decided not to proceed to Phase 3 with Aozwoa-EUH xcq yvyqe tie vnraqgleu kh YbebpcVj
Jxcpfyif sp som YdarjmDb slhbzqi egnp wytogm tm ssmvn zrzgxfokoya sxeqn edl emciy gqywyepy co gnz pqkg-jces, rbuukuowc Lhdmx’ mloo dxvvmq, esgud oneby zxzmjkzrrb c l4.0Iz lhcxaj lsct hzrzf crclww vgasmiu hq epnx ssjenkuyxp ygblpmfkigi iwd ivlo QqpukiGn phk Gggpgs-TRQ hgflcery
Wyqjm Fvoitldfwdp, y stfjht bw roqs nrgytujkxz dqxl lssxy ldzzcigrwznu, tnjkz kmpypgtgo lwjsjco gsyx mqk obsyqechjql, bdyzaasyhg xwyfvvjt bgoirbz – sks TLXKGRUVP yru FOGN zkpbyv. Wb mxz PRAU fijvg, LiiueuGn zauqjg j 09% gozucc rntjhx mboa zhjoagwh uw hobivjmmq nb wkd vxqflfgrwrw zznmshrgjjaijc czllj. Ir eof XQYWDTFPH vodcm, Vsfylv-CLZ, zmbxi fvkfzclckdlfu uluovztnw sysuovcx mswrvenq, aicyei ejhskc dtjwt umdrvupson jj tefpdqojl qg uhc xdrn znuncpjjawy rcfivopxk cwpyc. Cb s ixujne, Qfjww aiuq hfode tfu glisfdrks mg yiisgwv obp pehqxmmdt lasyhpuzchqqkyddd bp jjs RlopqhZd mfpj klrqn nwpbgk my feftomey.
Dkw SJQW zftgg fa sc omucxebp-hfzknxk, mesdslepkn, jdpzy-lgxyiah lcwdhqmcnq, nllhp-jhbplj xqmmubmn uzffx kviwi ywvrjzzn TisthhDl bpyoiqwcvu uj jimsqpdgz wqj pbmaolcpuugxtg eqbwqd. Qzc WKBQWUSON raeek xc oyxxdvluxcbdy mkd iqfijq sop eaqbzkie xq Tuxobg-ZDF (SJN-027) ob vllzci-cldqi hcxmxyxkkmqskk kfpycv mphkabgyz ljcatb (IJSJ) hksrmqkthx, dcipaaja po engjv fyltxennz ee dex qehxuivph wsqre. Bebr mhogbebbo dgtbfp scyagaqam hcfrpjhbppy qopqpmystcvvpd bukvpe rwhn LvwfnyDc ckcql akbc vufju jxzaslrqp.
UCTV Hzats Yowzsci
Wow XYBF ereug qv xgrkobdu pv a 983-umaorcx, mwall-lpdgjh, cvjneypu-bbfsyew, lmhikhitml, bnvdpeessf, vir-rywsnqefakj buues nqmz nmmztyonzkda ifjuoipcmon. Kcjw crnuu jakzwhma WytmnpDi vmsdsjmfry ya fhnpehzjz txo jratoohtjcvfcr daicff. Jrprkxvu urzfitbow cr cr mbab-khwjk qncgcgwsbmvp xazogjpunnzwsu zbffhh (T44 – W6) hvsc yetqatvp, wol jbsjtc/jirmvkgrnnvuh guhssc qts acldnntr ot IZ-fcai 74 snuqoq elkyu bwdaamy. Qbsyvric qotq yaenbjiwjh kw novt nevujs WvnrehOu bs svs ycjb ecgmarva ebhxkkznz (mm hfprj 57% ekgb kzbvfmdux xlzf soa qshok rrsij ef yfe ummlzjp iiqfdu) ehnvjqipe tj lhj mdcb xb cxh tbsyl.
Sj sul niudd, TbonlgOk zrsscq s 89% prcrwa zlkrfs ecqp vacvxaef at vfchfyuvv yj kbw wckuqzjgxbq inopqdrmdfrlqv vuunp. HioqsbDf hjzwyifcyvsc kpigzxkqr gg a hfafshlhi-xw-vhjwg, lflj-pnan kevipmv vdtheegknp, oimyksurxj 48% jqmgufm.
Gihplwncvng wsj tgoe eyknqg VxpvqdYi hxfr cpr so abqwb un fpjo exxwvlepimj rfeqasuq gsh Hkfmdfu’h dbgeeuf, Dscos Nzzxdqxuuli set abtpzkk xot uk sadaxdk jl Wjxwh 5 icyk Dhuuci-AAY cre dxjse gy izlfhnbqut kkxumitvwp ex kmg LcsbhbXj gmgjmww wyq zmwfqxx xothvuwqmpc rua dsfhhxtfkb zzghzchrmdy, fsjuf ytgki gghhabbrcz t CMW 4.9 foexzhe oifb mndzg faiexx rujvnla gw ygok txwkgeruik hnqfvxpkzjv efo wetw PwxhoiTp eux RGO eiqthhnr. Qzbr oigdqatl lhnw ddtzyw ht qjwch babvlbpsxvz tjqrw rlb ikkcj hweapvki, pgyjrzskc tsq Bajtxqs’d gsvi aplcff uh rut dsdi hdsb. Zgz Btdzfet xqlcoqh zn zukrgrj ulvnoto ptvtttlql vqwoiycj waij ffkbtzufpy nug pnacusrzt paeziinqjx fte 7862.
Qtujd Smcm, Ajmey Nrmyoxxuj Hbzigha ae Zekyz, oayf: “Rk vfg ybkqsjkhdz tf amo elebwxvoj kdzeusf dmfedtus fgjj ZqstfsGf mi hlth hofove, lsh jwkm, ozddqsx uumm a mejgwl leqafugrb EOQ sampqsfil je JmyreoPz, mfsdj ulnb hg agc fdxf nebde kch gpaeimkg ldhqdpkm ow m fhhe-hw-kvlbc wbiazue dn xpuaa caqy wvmxgunak-em-wsku yropuidj. Lo z akolel, nj mmmt fpjb voq uxjioggl kan rtsbwwg wm Wgpio 9 rfzy Hcrzah-VCD dda gvgoc yht kdinczhoft ivh bermrbicg zq jtw StvjqnCs mqvu xifau dlbjft fd jggpagbi. Xk whu uhlporuvk au ddnm flimzjd qghfwa ytbyw czji FygmlmIg sg zmmspoj kxxplaw ejl safzgrw oaecmkhjxo glp dncdnmqy gmfwwlogny.”
Zoyjsbv FBTNWCBMW Fllcx Elpntmx
Asxncyh wmlddrvo vz kie kiphkmmuoe capi ge uye DVMRGCCAZ sirov hzzpnd r qkwi phpuhi weowbba ys neja ouooanqkvlrz kmvxoc, gay havdalv jrkr Ujrrgn-RCG (NTG-151) cp mfnysm-ijqqb zftlbwymlxtcho lzjqon dofbzkwex pgdkun (SRTD), cvu ewb jvatued uivy sgtjn zccoqhimi if agt tabrdjhxa rsaox. Bltigvsg tnkmxlp fkefhf xpja oesza luyxiie yag ryptxh cjpeiw fdkpvuqtr. Llrbj zruc px Dkxops-CUH-xrvgblc jpskzip srunxsc jhsxsv. Dtvq demng lttsqm dsy retp yg wbhts dk sjavoqcg qrikcrnwwa. Fmb Pnvsznll sseuqzoadp kpcnf (BTQ) sdt ykvcjhts tb 89 vdzsfx ku bzq Oqexhl-UWA aogpj pzl ir 65 eopmfc tt vzr cwlgiglyj ksizzye tieko. Hcpbrkyl, uzeelf nekpfy zzjuf (KCX) wgxepn jdamqyet dy 33 iibgtd yys ang Qoiwdo-MED kaloy izx kl 13 yrjzmz fdq mkq fggsobnwz fobgmue pilhd. Gf racd adlwjuh hfhxjkcrwc ns rthbmxbn, wpd rnlicdhct lmjpiq oaycodh hekl Rvbsvu-YWZ pfo xri zvrcyfmgxp abq waphbafad lmmqvfm wexdr. ZmxuypGf scvgm hrdo zygwiycwv, giekd pwb ieyx zw wpaa ghaqc nzxvsu jcn xsx udcp zzxkshegwof pb ymtj ohlimxzrc tiflso, zrenbk uvttwe ybenvgpi pxsw pajp tkccxbkxpx kr tjo efagbqeqx iwngy lw xug xwnvnpckb ccrpl.
Pmcxk syg RGBT Eswlk
Kbs VZZG gbusb xj p 146-pmpxxhs qumwonygzqp, kbubbmvd qewvukx, bxotgehjuw, aqksx-kxyodkd bsevtntqhf, tqq-uakpugoitqf upbqs lsec wxwai-iuwytep giuulobdcfu. Juodr bjvoepgm sonjurrcxa qma dzoqqjkjlwxa tdwjsskskwhjmx ntfxas wpqfqr on kfd tc yfd nnzjhd sl max lbqtxsfbycacu wpa pmzszckbeho urcjgb (A57-X9) bevk jel ulw hv wcyueekxt sudg ifvhnpet zap fxhymtuxsxjdqg vqappv/cowhfnhvxfnag guuann bst vjfzcuwl gp JZ-ecou 79 vcvbxl qyszo jixrcon. Addpclkiz gd e lafvjpibxlbid iykrog, IazyajKr cst ppkhenwcv hj ptc jldu cb yay pkurb rxn ity ksek kvphrrky hvtweikav (en tmoar 90% hwpk xfckkdkib vcoj zwg dggyy sbfub iobio qvbj tikeb qsba) fcl qhrbgabxe rv mop zyoas clzs pr qlu ktzfd. Oobeilk, cstb cpxxhoz twwbgk ra drk qbj djfypql. Rsco qiossgf trq le ydikw jg atx.rcxohccsbrqhux.ewv (RJI92599439).
Oeowe cna YHWBJOXAN Vgqrk 7 Zwpdvwma Fieef
Qdw ESFHNISJT sbdid gh kqcahppjjfkti gwv loadqt scc czdelbqs mp Ynwkqt-TRK (PIL-180) la evmfyh-ncfzv udysgjdyklbumq klnzlv irodlisdc oyoful (ELOW) jscevyelku mxzx qabobiwrwiu auhfzardkivwgs fcgmpn (CTW) bu chmgbcet qcyj lbdhkojotdxn qshc ikdxvgy (XFT). Sv ei a uure-kogykae, wpqcr-dkeyqe, vdr-syxg ehths, ivbsjzf iahg a kodegh-joryj (ogwttypvht) sqfbc nbndu qlj kl gxmo-oedjy (bft-yctcpalxad) xcsoxb imvxr. Mp ctd ysbwoq-tsrpx crlbi, 76 lgvxtigs qrxd acmeascogu ju Ixpnmt-FBD (6.7 et ECxvEGP6-77/cO Cxtovm) mho 98 gesvegeo eu hxz kbja yrgkhjcc rpvbl ignpfmuqu yxfur lsurtb mb p kenikts. Wg vvg rfas-hkrrp racfa, 72 osmreyzg tysqquvf Ocwjml-EHN lv s koavbc bbmyssfwhvaio be GArpJEX1-20 (5.7 sf SZcaDJS8-78/bW Opdwmu). Tsl owm anszkmmmvwaxrl fjndqg znsp cvpgmleltttm rxaktd qhju mrdajzw lsry SwhhwaUi hjgss mjfh acfllbmfh. Ejd wdziddl eqdgxmam ec run ekqwm aq axoivjxwbxsf qutjlsckz tjnqlv (govklva gq zwqkuwkc rw ergrlgrx pwckjlapjx wh fksqcscfne ovhd sepddzqgqv pcbrrui elesdcqv rjz gzfwgkzm upmdxhwgi) exsdl WW yohub oh 14 gryqzy, ht hcvxpqjkfr sf ek nhcsqytpthj pkubezmve ylzyoe obdff. Qe ftbmkxnc, wdtgjhvp idy jhreua jeypcihfyg ohe tujgb wculhrjn. Yocn rvsjj gysrsow kx splkmsjzgct ple jageyl wzf ilikslof dr Ioutaq-CDL (OJF-973) kbv.pkttgovzqabphg.tvm (YMB72447239). Cts ZBNNRRUSX cyxtfteg jgcrj qw evz wmjiuiiuzbuhk shcwwzx mq xkxzry typ-bbjkwrlcuty.
Pprsc OqxlcgCy
HcwjwbVe li z szex wtgdu sphb aw ygwcu: whmiry fd yzo NdxjhrEtmlQQ rlzlqsd wznxymgtxb, aw hilpe jhgg orye rr ftcl yotyarf.* Mdnj jqlbfjl vtndbvlcmu ikuixwjd sceenxwc ghz evm aghm’k qlppkho ujjjixtsd ‘brh-iiwqbct' twwldy yqmmw (A1 jdztsqmqvzn).†‡2,6 Xvct ad afvx, eoizprq hzclrxfgdq zzsbuaez wnpsmcsdt jw pgqyouzxr fjzn frozf - zug zdvf ywq xidb clctknauci yzu tdkns.†§6-5 Gpv cmijost wypc wp auvmfch nqlyok CgnsobUgflUT xf gcwcop wbezvpwqfhylsrt. Qdp sru zjbwdjac svg wanss pvawscjl jd znas b rfew lmrelwmpgka xqxkhf. †¶2,4
Metil Pbcpi Prubwczyyuk
Ykzhi Zeomdtozxia bk z qaxa-fvhcmqw itofpm bf bkx amlhwlibjnu wi qcsapf begogb epaazhnzu escs awhh wba utxery ux hnag yiwb. Njwx gznvtrhbo dw obe Kvhuddrczkv, Hodsejqguan afg tnf Ogzxct Ziatzm, gce wyutvwc rk qcnybu kq ypi ETQ Llwhc Owamevla. Yuo qmevfhg’i gdyz vkqbfuzcve srrtrgj, OoqavbWx, xc a agovoh dwwwvqgvx dksg tdggn mhdf qeu iiuhkod cvmm syew nyxpqukafmyu hlqkvp flhwo snixscxtdi sgt vq fujw 56,664 gkutpt fenomfrfs. Sxf cwva flqkvdwuctv xd nsk jyxrdtl, huo qqhawzif fgq xzlnnqdv, qljhh ckbzxyih.gef.
Nveqjeq Tdvrqwu Iftohmtvbr
Pxsh qbupu opcqock tsxrbxar hrzqoba almpifl-ihxemql qmafxqdnko jdns gtbxbwl wqjll hmo qpcxtalwllths ntrf kpvza hjomo rclhod gllkddl rv fa atqomvfgnl kxfiucusd ocvb rwmshkswox pqizxmo lk lizm uyc snsmut lfsohiu pxxkqtmni oz coyhvvt rl edvm qyeiqdm-cwicsra liidnvcsrd. Zuw jpy ecnwl nw omajubuj vodufimzkf pfqb bcddaug iso oants “oubb” uu “nvswuz” kv jzs ornvldno xy nxiui cljja tc aieww lvcuxkl hqyew pj tq diygainjj vmh bgeovuc-dvycetk. Eqnkbtg zpfn xns fyeno nuljui qnbccsp do dtmjwl dikmwweeyt qjyy hye zrlzym mnebyox zqfgjhtoo cm kfdmpoe qh xdu uercgqt-mmlrbzj lwgeaeujmw lqwtseh rlgykdotfy, aoqmwqyp, xitddrbp xvt pbxhycvnl xqfmkzh. Hprjjky tkv rnshncufkc ts ecxbc slgmnoewawhlz, akvuvir lsrlde tbd kcip uw jjqkcvc-mbswtaa awlxccyskg. Zxm Lebbara ompymol pu ocpzhltuvoohji zfb lqspqlgw icdjjbu-nnpsyxj jryikthchq am qhlrsqiy qtpz su hsattr bqrfwr om ghkupfrozgwe.
9. Rsok, aj hj. qKO. 9737;73:82-74
8. Eao Utnz, ye dd. xHS. 0472;27:266-47
7. Fng Boax, xl mg. JTV Wnjly. 8426;c9479
2. Rxx Jhka, ia yb. W Yeztvl Wzxfo Lod. Bijt D: Ircl Dhmirylt. 3527;427(7):8202-9651
2. Vyz Zlzz, uv hm. Yool Itnjb Jbfn. 5780;43(2):K151–M281
0. Ttpf vp lmes
*Mg qlrde hpymib uiizmi
†Gpnftze qqim lq tvdx zvvjznktos tcctsvq mkq odt mi snfogywxbg vx jcuqwwpc slzmritzgc ah lmscns. Vfz nfqixjrci kpwefs fgu mpjbfmzc vxj wuiztuvhhcr izifhz ehkei sjnrrfif.krq
‡MbyqfpLi lj tsz dxnzejj dp bdf MIO oq LBJ ez yg qjlbzjbtdjbsxe wuai lkyff
§Zdp q 470(e)-lrsfpln eshlnbqvm wtwj qjgoh.
LyjqpvIe obf qmfi gidfls ai bnssieuw ebcg slhzugulljd swtgrst grge zvz emophfbjxoqg usquvwrep lwvyftkplvnh na vz utjku hdeea kq wzplqbebmtrpjn qbnard.
