Different key figures are decisive, depending on the respective process step. For the scale-up of the depth filtration step, for example, the required filter area is crucial. If precoat filtration is carried out using depth filters, the cake volume must also be considered, which is usually the limiting factor. In the application note, the scale-up of a yeast cell suspension is shown. Due to the rather low yeast cell count, a standard depth filtration was performed without the addition of a filter aid and thus without building up a filter cake.
Read the Application Note
https://www.filtrox.com/blog/2022/08/02/upscale/