Finerenon ist das erste den Mineralokortikoidrezeptor (MR)-Signalweg beeinflussende Medikament, das in einer Phase-III-Studie bei Patienten mit Herzinsuffizienz (HF) mit einer linksventrikulären Auswurfleistung (LVEF) von ≥40 %, d. h. mit leicht reduzierter oder erhaltener LVEF, kardiovaskuläre Vorteile gezeigt hat / Die Zulassungsanträge basieren auf positiven Daten aus der Phase-III-Studie FINEARTS-HF, die kürzlich auf dem ESC-Kongress 2024 vorgestellt und zeitgleich im New England Journal of Medicine veröffentlicht wurden / Weltweit leiden etwa 32 Millionen Menschen an Herzinsuffizienz mit einer LVEF von ≥40 %, was mit erheblicher Morbidität und Mortalität einhergeht; jedoch stehen derzeit nur begrenzte zugelassene und leitliniengerechte Behandlungen zur Verfügung
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