- Finerenon ist das erste den Mineralokortikoidrezeptor (MR)-Signalweg beeinflussende Medikament, das in einer Phase-III-Studie bei Patienten mit Herzinsuffizienz (HF) mit einer linksventrikulären Auswurfleistung (LVEF) von ≥40 %, d. h. mit leicht reduzierter oder erhaltener LVEF, kardiovaskuläre Vorteile gezeigt hat
- Der Zulassungsantrag basiert auf positiven Daten aus der Phase-III-Studie FINEARTS-HF, die auf dem ESC-Kongress 2024 vorgestellt und zeitgleich im New England Journal of Medicine veröffentlicht wurden
- In Japan leben etwa 1,2 Millionen Menschen mit Herzinsuffizienz
- Etwa 60 % dieser Patienten leiden an Herzinsuffizienz mit einer LVEF von ≥40 %, jedoch stehen für diese Patientengruppe derzeit nur begrenzte zugelassene
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