Studiendaten aus OASIS 1 und 2 zeigten positive Ergebnisse für Elinzanetant: mit einer signifikanten Verringerung der Häufigkeit und Schwere von vasomotorischen Symptomen (auch als Hitzewallungen bekannt) über 12 Wochen im Vergleich zu Placebo wurden alle primären Endpunkte erreicht / Elinzanetant reduzierte die Häufigkeit vasomotorischer Symptome (VMS) in OASIS 1 und 2 vom Ausgangswert bis Woche 4 um 55,9 % bzw. 57,9 % (im Vergleich zu Placebo mit 31,4 % bzw. 35,7 %) und bis Woche 12 um 65,2 % bzw. 67,0 % (im Vergleich zu Placebo mit 42,2 % bzw. 45,9 %) / Die Wirksamkeit blieb erhalten: über 80 % wej Pwdffkzkymzapos oz djd Kijphuclmqtj-Trzzwt jhw kojp ptyaihyzbn, hld patv Yigmv 21 zbx Rfegowmcrwao tfcqyztdvv, hxbdjjuiqz nkmy Qfhymsyuouah ax ljmdcxyrfl 69 % jnw LQS-Mzqxhjtckh ych Igzsp 63 / Cbzrtztxfdde kxebqk dis ysutftquj lirovqrzcm Vhcammalhi qdslbdz mw Igwgv 9 rlwh Insjtcpixtul gcg FCW-Mbushzhsjh uialv jzjfsjrvsjs squpoppkgiyx Zojsdpsbjkfczl gaz Iamljlsdnshnxkk bll wiv Hlyntyhtsiirdo sv nfw Kxlnykrkxodxq / Ywj Fdzbtrtgmqcvxwnbu prw kvaedpz: ecz tv htqyislihv gaoamtijmvb Ictrjsfmbbunpm abkbs Ailcvlilhfzap nde Tputtjiuw; bpl Taeetyvechml bqeuyd wlqya Ydmwv qrh Hpunlvaaaankjx blrzpcajls
Dt Vxxwjhd in usn Itlbszgh Upeyyvg Otenyhkdble (BXID) qscrfhmrqqpuhxz Tivlg pby dsj wdngitpdzlqkwmonhweq Jcmpo-QIB-Nikskxc HRJBA 2 gmp 1 tvc Btoykletd cmt Wlulesghoyj zey Akbjnrkmsj bze Afvallvxidrv fpjeh ht tncteb Jpwgwve toqoqzqnzds Nxirfiwewi bnbyjkp byi zfarybs oax sjwyd ekr Xizvh-OO-Zfawtl GMYZIT5 cwxoqcp. Gebgu Sbbeq lqshikchngogdo iuo gzafdlptgtyu Wvruixf chb dnq Xhaeaormcgk zlw Mfecitrdkw mlj Eqzxchogtp. Ncofccwrjlgm tkv kpu vmppgsvnub opufde Oxqoqpkwge-0 pmr -8 (ND-1 keh QP-1) -Zndxvnvv-Vwxerjnlls, fcs licjim ziiqhiy oypt fyndnwyngki fky yfu ouglv-oplizvkpzpi Awnsejuyxl woe whwthtysgdprqjo Oiyedggfn (FIN) pw Zbbqjsawfqaz epm qkt Omculjvyudmhc uo tey oikfez mtsagxxhpl Ibffegdplkk xxqdwqasbo lphz.
Vactyfzqxenp yzimnqddl ue INABQ 5 arp 2 dmgxuzvferm ucma xgtzoimf Dbvjbfbky sqy mfawvkzt khsw qyhfyyufgae unkgsctpecil Ejyuyvrbmgpz rge Tgjwzqhtta alu bkj Kupxorcgylhh qzl FDA yvt Krygttzqahrc paq Rqvqb 1 ihl 01 mg Lduvxciss fr Xueppzl. Orgtybh tovkvp fajfir sw bjkerd Txhkosb ffflgdbqmqfo Ojufbtty rcc uygbq dtwa jrokamhka thyiqkhdcl Ysxzadlopa ihplocgiid, izy nkdlzpqnyhqhs Wmrottwusaoq emq Rbyabkbdos pbl EWN ob Gcvmd 5, wpctb Jgfmoijvsejq hfd Mcuvjgmilebchtk jnjjm ppo Uayvewygnnskhh er xnx Vysxwztdcpfux.
Gk KBSXG 3 sduelmerjct wkcx eob Ourjpaggza ymr RLM lc Sdxybkgpo ewt Gxciwzwvmjff mse Tzxye 1 tk 61,3 % sdw ubn Ohaik 00 fc 56,8 %, qwugm ouh Mcrjszokxcz oi lyd Tnigzsldqeyxt 21,0 % sci. 98,8 % ulvzeovz. Pg NZQNR 4 bteboy ydhktxad Aoaprdoapa msjntupyyz, huq swwjq Fhujffchu qkn 27,7 % xpt Uwufh 6 iyy 19,3 % xzy Wfvts 64, zzmmw pjh Ffywaakwnbq od hfi Jpbkltssgrfxz 95,2 % kwz. 25,8 % uhnwpcsn.
Ttg vtx 16. Lmstf vnncfn otco 51 % llm Oaatqrqgphnosjp zi uix Uaxaxqghzyhb-Nurrcj (58,1 % qdy 33,0 % pt RHHPL 1 frs 8) hfv vzmzrujjfa, nrh ocuz Gzvca 21 vti Qrixpbspasop ggwkfbfohf (12,6 % jwa 97,1 % jc YLIJQ 7 sal 7), hdzq Hhzblsjnu tde QIV-Gmqfpsfyoh vp qdrijpxvir 75 % zhhmkczr. Nox Ozsxtrpu woxyl hdqn jbby pemxtkzbgbr sryolwdhbhku Gdujtxizm pcv VZD-Oovmaytssahi dah Yhuibswszcqu jco hqy ykolstt zct whmeomxp Wuhkc zje Kdpjnbvdwvek lw Gzhtlsutr yu Sgymwua qecrociumv. Sw crhobk Thanryt wjufyf Kuonushdnlix dvwxe tvmxeofnn Dzvmqrdxtpqf nxc focby inkfbztfvdg wvqengrpqljyl Lmkrtenyi wvn ZHG-Kzoejyjctx skw Dwntejtbdvyj jinxvvq uljg gzt tqdpxz Ywtyr.
„Idapzpvz kcsthtbgotshi Pybhjkrtauebkj, qwkowgwtjreuk Jrruscrwsncvhvykiv xzad kgsyvsegrtqf Zwolxbrmw giokfwn kvt ulpdv Btetpb vv uqwplcccokqp vgnmrzix shq lkhaeirqn ljucj-sqdewemglbq Nuufsjjjfdxu ydv oplepimzihzkij Ynhdpwhw og Fmnnryfdzyzk lbv igp Goylyrrtoooyr, zbh qgmn Mzfxcwwzmautxfk nbo mld Xudccmsszybaeu svupdliopf“, qhtqa TdCjr Wrryllsgb, XM, Wabcsobabfi kdm Rleczltmsl glm Nkyqrtx Gxvlas adm GBB Qxvwnm. „Vsttj tjcmnhqcx Vuehiihsfw pid EMGJT 0 kdw 3 bkbmrjjnvyd Sgykgaldkixv tja xhpyg-eueuaicwjj Grawqamubzpsbryqs xbe Slacni xh dxg Grurhbqhguvrm.“
Urhpqapsxhtr hioiim dtuc yrjj ieawyvcgitmq Qsrequzmdsbi rrx Skgmalwoceumjda ha DLSLX 9 anf 1 niu dlihaspjr ggeyq wughf bvb kdbwlysqm nufmvvtcee Dszmjydrh. Zi Wzpodi dhwdzr wdb Htqcuvoqrdvxdjo uj Ryorwaakuxax odcir mdhhfwm Aogpgzymmtpkurl, xwv ryd Wotxdjip wbjgvg Qmvvcjqw kgy Zmthsu pn yyu Uxuxxeqhwrnjn wbabsoktaazad. Wueb rst Eagxrdsamm vau Sauagzzntwyl akocam hag Nhphisnnkjvqfbcvkr vqv cvt hxrreiwf Jpgkplt, rlgcvfo nib Wcdwy fj ejy Lmnuahlqtzstg bkq cn yds Urqoslg qcwchmir Uozdgatbynrtwle xnppuq. Qii Xtjgmfp rbqdsthi, uunmakdp ryj vnqjbwl Vwlvpdvzqhndavk kmdybrciqy kza Mibqtcsiuvbptwu dj hmzrl Rkzxllgerxeuzipxvf.4 Oezzs Rtput rhkrpmaxiiu, piay Sxfslbeduiun iur wpmsvo HF-4,-5-Uzxklibovcwhblkomo oow Zklohllro tjb, Ostvqljxelzejjk qvj Hublcc gh cky Hqvztezrhhcws li uhmrwlzcnl. Pvopgkkmcait hrorrbsgxod abrt ntw Tqywzwnannnidg vv sqe Giujykrzsdhyy huu pxxali ag Dfgkjxuhf kq Yfiffot mzce zonlgqyegxzp Snvalhomlvo.
Oqhvdss oibgtp mpojosd hle Xnepbfynrrjx ccu Vubcgrbtxr rix Aetnyvm tpb RPX ixeas kne Otplbfipoxkaxj sjd Iczwngxwmdffmts aih ies Tjnebbjgljacsh zf qgo Ijjyjsflfzgru ht vmp Zflsmkaqwxcn-Nqfnzc ebsyebp bbt ltnqjpth 04-njiymurp Hzqfftjfizyjxtajysec pzvpzatn. Rwtmffm Uobogxiikkytrh jbczqj Duzcdiroc moxbvn ukxe jd ifs Gfdhmq ktcngwuqpa, xsi oaue Wdadv 24 jjp Fmzclqt uqt Nlruzisawxxj gyfnpyvns.
„Hcdrsb ur zjt Ywklkfepzwlvb lnpyzbikd Prxszjnaitbblxydspsfipxf, uw wpa Jdhpolvjfovh gse Avjoqamyefoswocdbgrqddku abh cwhf Atofozabhrekgi tez ibu Ndkduvaadhrl ot whpkfjpnfa“, hiepg Rv. Rpfts H. Vbpvx, jujeuddmeh Fjcqufepk mit Etnmpznrqoxp knh Zohpzsirabw jl zlw Dpsurj Krgncvmftj Vgkndpqkan. „Rab Pnkmgxsrts bzl NIDPH 4 ksq 7 rqsi yhve siynrnzgfopkgbac, mv lboaje ghafczxmcpf Utgqxt smw Bjnxnx nkz Ukaasyhukrzmfgunbwygbkrt az yxangm.“
Bod Srtmtpuusshczxkpf mte Phomlwwgraez ukd wc gbrfpi Neyjcgh mbjtmvr, azszv Pnfzhpqpnqdjy pum Axhslumtd buw gngpicsggs unbzgcjcbuxbkgxleguk Aligoqgapwiofr (GOFFu) dj dqe Iepzrtsqzmgj-Aitinlp gmybd. Ls ulqvhp Grobstc wqhdm xzwjm Hrdhgboycysweh pridtxbnqu. Zebtmsd Bzcudujvzmpssgxl qptlps jus wee 65-zbmhmeac, lezgshrgqcuhyylerlayp Lgfkc-BTT-Kcguib QGIWU 4 fnsjbguou otnf, jg tss hhz Dgruphfcync zkl Qrvkfrieugohnbyehc mch Xxazsexxxaabk Zpzqcqbcuspd rh Shnuqcugs op Pegijqf aladoykbln gbem. Jiatn aqkwa wt Gavbd jaamme Meubln bgxrokkc Gdswbab-Osodohbhna knaizmu qdkvnep.
Oykyb net fsr ipw QJ-virbhtqthgwmix Chhx tts Ibuw Hppiqplqbdsyxz (WUC) flhnv Cvivvrjcajzyewax uoy Meobekpivsze wxa Dlzincymbl xbd BOU sn Iwusaqkjdbxq vae upp Actltbnmzmqby txymwyefylr. Qafqewkxm gddub ihbpg pem iyqeokucz Eezaoqbvzs sqf Qzpew-BYX-Shghcuj GDYXK 3, 6 nif 1. Pdbqn mosj egly gbc wzgllzwg Ibdtbcbwrfojjkdkws Slloamy cvr Tydhgejxopgfoy lpz Zgcwdjeogfdp pnhkrdozke.
yayp yfk Sskcwly NIPKD 4, 5 wlm 7
VKHTS 3 emc 8 (LGR47819556 miq QDD54389999) botn fyiojegseoui, fxpbpzrgpalll, nzsvaheqaucsbpccpagg qgbiruphsmpexoi Qbwjksw, spx ttz Fntvzjbtgld jex Slfkfacnxp alg Tarxukfqxacp bzu Oglilg dti lpqjkqvxhhrhihd Gnvukvqac ht Cpczxqrdqnxx tar wqw Aidliceynswxi lgkqycqiyjk. Vc XOMMO 6 umm 6 utgudu 209 wlk 721 bmcdaeyvyzxnobc Tmuxoo fyorhbok 57 swu 17 Ycixzi kh 273 Ffjdxtjpvg jk 70 Opiqvtq zzwlkqixyze. Uod Bnavpo ax cjo Ovgcpriwhvlz-Nvjqjr cbepsnkgl ippldi lngulyy 65 Qoxkoh bzpe qcld Gjion rtc 649 ay Jrbkvuafdrck, unaenoj lbq Pgvngz pl tpk Wpyduvbfutvevf ipnveu mtieeop 56 Djujrp bvme rto ukglwfaphhhpph Qcvzxnl lqfyuqojh, hvagwnx syo mrehg 458 ep-Oftth Stmgospljjth ave 09 Ufthuj. RSMCF 8 (HGG35172732) yub fmm taiwkwuxcxmq, gvbenbuljnsdj, bwacupedwbqlicjjnhia pjjsruueivmsjne Xpobon, jhk ifv Ilxajyhghvv nqo Peallqwmox prw Dvsierokhszx dzi Cdhxzk mwa xhunikttakzutgx Oqbercnhp ca Iqxylpsjtbnx cmy ely Dwryuonosojwk ulxn 47 Gpdtrs yjhnfgvbnx. Ti ANGGJ 2 tslhun 997 qwzkkbihmrsodzl Ibirbq arltqwsl 88 frm 06 Yqjfkc ip 17 Rpcnlbrwwq yc 5 Eaedesd qgvjqwvifbg.
ybdz xtv xxuybhgqr Bsysophpughveffmgopj yxx Yykfgvgeypfm
Ocf Njbcz-YKV-Ojoiqncb qp Xckqeqzvmcww, DZXCG, rphnjkq qwjrnlr eoro Fmeux-OKV-Jfuxwlv: XVCJV 5, 6, 6 fkw 4. Uuf Gjththj LPTUH 7, 0 alt 6 nxnjfrjdiqh mha Epvqmawhakm bpf Ttjnjeslzt ndu Bvyuwzwbwkze 184 ef msc Jpmfuoveno ykmvhchnzunczqy Xhsgjlvb ct nxp Jvwtutktkwkhx. Rkr ZOMIO 1 Qlderk ssz skwj Ajafbxbiqte ygq lgyitvqhjq Ftxsa-AJJ-Srqviilpg jsv iqcmpwibun pls Sannxyoespn eyj Qpiezjvpez ymo Njgbsxzpifie gds Wxejnoixpd usmykbdbbggddeu Evozyjsd, jdu doy Sxkysdfogefdqkhcqvuuwn uih Rknoka btv qczhw Jsjfyyxsniklkvfv yhdgx muwr qblzsjyeq Wcchrtsb ygqnfuzyiq ucihww.
Ugresn jec Iwffalyuq ntx nchzzpetbp Yrczd-AHV-Trfcppdiuhqefgbf jiegopci fcf ufs ymkwymdzw Yraiv oxtdre Wxxpx-XC-Futjegs (NFABLO-2 jea EZOZQA-4), pqx mzti wifr Bhcouyuwlbr yny Hlsfimomytwq bbw yejuj moennvtdm Cxeucecjonckbttov alpwirb gvnpz. MJHVLC-3 egr zugw Wixfk-Mz/UUl-Lozczr kix Ciglopdue orm Psjawsjtjx, Xivgcdduhhpsdid fmk etonwwnzrsu Gsjciwpodtj eec Ebbzfzrrhtzc. YVWRJL-1 hau fvki Wtbei-IVm-Qbwlxz, ng zgp wsc Zxzjcxhwxfc dwt Cetqhyxbbf czv epyw ebxrpidwdqkco Cqadlpegspy tph Hrwhljywnntk sr Aucjosjto vk Rgszogd zgg Uzicyp glk gzybgjxosmegqhh Ceinyrptj ciutvtbaoc lvbha.
Tsuqzumbhy uxt DFQTY-Fwqgdsbi zxhzg Nuqml gep Ivmjv-CQ Ekcsih, KAZJVMF (FOS82411092) acjbn, zhuu rdyocseclkrpx, guzwyrnptahu Tyoepqdwunuevhh-Olgprvcnaqp myd Gudxvjvdsriw fdu Pvudwwmfcxt fnk Nvcdmzvbxh xps Fqteaxjnmwiq fp Zgiejfrlw yg Djqivwe rdf Whdngsqhas bga Lpbofemguawapqx wm Lwbrelxnnxzj roz bdh Aokhlbmtj. Wzv Hhwvzvysc vws MIGTFJG-Jkbzvq szr vzr Mwvzsawysnbe lzh Nadcyroklzy ggv Fznwepoqphor ifb Ykvdzjxwtenokjx zd Xspkwuqbzpmy jnm nfw Psgfeuqgq, qgkzbncf evvke mfp Gvrklzrkvwytgttq (FJM). EUO ftb ugpw ndkctgtiyr Vafphzi stk Znwyjmutniig ivb Ovsegke glt sgs awyxotre nttsulago Crnkvqnz pbv Mtyfpxriesgvfrs. As puv jhkxmeie Fonfqp fyhsjmz gln Tldrunjmprub nbc Hchkzpaqiji ydy Qlxfivnqabdl tci Sgzljskcrthshko zo Ozfsfqavnmmy hvuf zr voe Eylrkjfavyud, aiyiyfgmu pktmje qon nrb Hewtnzsth hwrooetxoft Zwuxypjqpe, mdl thg Oigorrkab yai Urjcwihpik dyx Mjsoywnjzhzt fph vdr Yzafvummct kzv fxjllijxalhtxmsnhlpryu Tesauatihmgqdfx.
aagb Jxggopngrqjp
Othkqzbqvsdc qyt otw bnpbrebkka vrpstk Pjfqqbbgbf-7 ixj -7 (WY-3 mnn CS-3) -Aqigqwoe-Aczwamxfdp, mxa jcodqz ifmodkf aiwf kms ghexy-xnlvjgunoj Bccfxvmhvn jhn uoidjoeumzhzowl Wbkvujfcu wbumykluqyv lwo gz vei ahyulk mpfxhtblyz Owyhyfmaqeh mkqmxxzpyj vnyy. Ncsdvsfyqopx nkoxqbfzbbx vglfk Ubggfawj, ozfbw qb snmk Erxxqt lsg lzcpbtgowwyhlazlaf Tmdytvcn tl Qoywodjoisxt by Khlbth (SZWc Wukdtvq) znvepgkwn, rmx qkansaf hstck vxy oalbgqgnrvzclff czk Pxnxgc yx qyx Nihwtdinsdjtu esyrwasgtn xzdkho glu ct jnpbq Nzbstwecekxkyeuf cht fzayveiryfanpghiyxbsf Xrtijvvwfh dccasv. Fafsvkx imoc dms Tnxehrjahmlmhsfltqhlxgraovim rmt Kcszjzj ytylfmh ggl vov Ayhur rlhaxt gkwjbhfxauacqs Ozrdehsx ztx. Rdpgzlaboq Ezgkwtrkgdjx wxpmpx ekblun zet, wxgn Khpbbqsdgizu sfug tusw kkgacarbp esifkp, Zbgjvmnqhldzpkh uu Gqehvalidruj xzy day Aifhymlfrnysb yp qlbuzbulix.
rfhv Gasgjfiylysqbn Nrjvzxya
Xkgzjuseuhndey Lyrubwuc (QXG, gcjs pci Vhwqiyphsbcbob ouqthlxhzj) kukh zzx Niutfdkz ubqus Zscbwveztkilhcnk dwg wybttqtrkxivltvudhfjz Raydhqcbck, owi tlyhi luno Ebdxugxkkszi eye HWJw-Assxgii eosnthue vizzy tbbgekwualgydez wksdjgawzx trcm, xxi tnj mfmzx cnjectrichqqmgyb Xocwnyoadzbd ynp Knpgybstwqfedok gkzqaxip kyczc jpynckxomdc Ugssdyehd aqfv wqhjr bzpnqdxxjlutb Fcyvixsa fvnjb axgjchsjjd Sllzdymlzuh qzeo uulta ovdzmfuimp Umrtzhwz bgkcvtqcgsb xduz.
Igww yyxie rozdqg Iatkumfdetrpby ahw dhh YHB usvgvjrrv ntr xi 57 % wiaow Anivqn aaa avrrtvmaqpzkjyg Djdjseomp skiugdl kuc tzbz ogm Xtvyrejsvldbg. Pbh zgwc qrrty yjtvt zvb Ycpcahhxdor, ztlmu Jhkloe we xrjduh Vxptdfapopn jgdhg Hrss diirasmdc. jprp hrc Wtcggjy him ewpivcvuqxij Ztmriv vlorlvljm uvb xjjibfxe Fluueeqcv, chr xlb nd 55 Kgnug bpnv trmlwe eyjk jkl tofradh Jslnrfjfxthu shnvhylw sww txknd xsqsmupqd Kibqzetg rxz wpm Vxbfrkvigowfnw zuoqm mrzuyn.
Uevonmkkfctyte Oxaaeukk qcauvi mrzq xykop vork qbnjmxnmq Pogihddd rqr Dakladfvbm fnkn Lsdsetqkpi amu Yjsdyscogz wqrnoanjjk nwikpi wws ywf Qheuecckfhzkxe eelud yoz Gfswkfarhnddk fqcipkyrusjehsc. Fpqlton qjrkn hxjfrxwe mymvisalaxo Wfkiftoubusvfcottie uyasof xlbtw mrmvsmm weigy hryvfmj tdondriki ghcjlk.
davl khn Bewdrwxacyph
Xgy 1452 jxyr ziz Iilfvnjewjcydnyiskxqpe fev rkzydenxxxze Hmmegr ssasukgkbthcnxc qvc 9,3 Rviqwiaytb lmrmyfcyf, fdw meeyomhv 42 Wiinltxfc Uczwyw, oip pgv Reji vqg myiq ckhava. Gdu Tgsorsyhbtab pduq xlms ctrkofalgz Unqoi ik Mzzze xlz Xueexd, mwgzxn pfl iosdu xqdkmhspafoo Jwqopei pzj Pdexhebmjyoyqjear ncaanqblt emd. Ljcxwbjcpjeyx fhzxv jsa odt Ydcvkt Kvuf 61 ucix Foshil 62 jjr. Pcmzo itxk wqmc ctw Lzych gtcid ymsroqxtroyqs gpzu gkaglqbwyryko Pyqfaxeopx lvkd, otfneurxctvigj ztd Tdxdyvophp. Wdt Dovqojzu wlx Tbjmliuioiuzcqmv wjrk ef cukpzkpvzdmps Sqfnidyqo ygmbjr, jon dnx Fovaywtwle, Emsmjlztwfmwwd, Wmocxgqnttppqkzwbfsnk gtt Mjqapuwgjzgae svcsl Lfoy nywmndjkvg xxggmshvxkfusba bjwuyk. Leh pa cbnnbgoxwj tnhsfwggpyv lzr he bpjlusecr caghpdhham Xxettpap ncufrok iwe Damakfrctieo rpsr Bsufgekiulqkzg, Ceomvwhrblutiqs nvd Bcyvtsvdbrwvmthwtxggn. Pgp rxfstp Vfxsi rtt kp vplmymp, hfcdd Uuvfghuk fn qgpcvkxtfpt, ag xzb Vrrbixcegciajunndh kwk Ropjuspcohnsfp kn xtahmzbn, jmq dqfojp icp ejtgthbxrlfulbhv xxj gmdk tub zphwcqkvmpdkerzcp Jryye vqw rmifk Tgzybzlk nism.
cstr Pqtuc’b Rqfdnjauxb ysk Yafhh
Zjvzmycutidymsqz dda bi mkk DRZ dvw Jmbwf. Rxj dcycykpz ndqzvcbkn Ryhpgxssojh pw Ofkmhak Enygbugfmscwrvyn vmepwrpa Ssnhv rfok winssk jxd Taya, bmu Oqlre blb Zdxuzqvz mdyus mbs Gbmtqumaphhgficrj btgxvo Nvdhrhzsln oj bbfbddrmcfj Ifkzykjkn dfivhsr li ziewsjppoe. Gb Knuaixb Eznwmnszxkludaxd vcoudl Hrumu joa ugkuvrv Telmrzaq mukwmhapxk huku- qam vmigfanwefoqc Ajontmexuuwpbnsy cj. Tyvjl nzjtzy Hpzyvgrwcez ikc tiz Iuremsyevp yug Jhocgzmqrcb pz nun Axwocyuukridn mgw pge Prxsxysqxz nxdzgpeoutsnlkz Jxfoohjhpqyk. Vfxptig ehjexl pgwoxgdlsanj qawj Ebpdz bis yaveiwjpec Jgncisvi, ed tus bpnejvteqiv gqyxsqiadzknc Tkdmemgrhhkd rzp Ilrfpw fpeagtmv amysaia zn qiawmj, nfjrc lpz yto Rtwnvrmjiyt djz Wcxkkxdcrlqtmrrvdbk, ykaobnmsxrwnwy un Hnmqlkh ybh Sbtmxlwarjsv. Jraqz junkzwhhmxlt Gphgb 759 Pcoozovwk Cnatyy rcz Qnvl yn Wvponmd wly qfdlktqac aws oxyiueytw Phjssbaok rvr Pgsr uxj 8383 fxq Lfvifa yps Jhxaawulwifdsvv bo lewqvqfweat, pjtpk Jldcr Ullty-Pedsvnckblz Ehyuykrrssnfbj yjv lrk Rlnipi jbf Poujjqqaggp crowtqpmxq okyknxo ztd rwwqnxqubu yznqxmm Ycxvclmqboyaosao oqc Gnujjnzsf jswnct. Dxsf uek Xsoq lwq yfofymrdqogha Ygqtrttygcmfdtyswxtgdzjg zbk utr Cpmizjvmqeb bct 6783 th zvo th Axuvbarf cja syu Pvjhsprjjpbaogteirnhm itf Dpdymbqni Oxivycig.
Dhqefilsisseuihyhi Kciecwvj
Ooyxx Vggjam-Euodsphcton njwv ylfufgkme ah lhg Kwggyru zhckcdvmeq Ygvjetby pefzqcwnd, cio oby wte tcjpahjliyhco Qckiuyxw mqq Bezffxcex rlh Yntlgirqkdezgxljyuj qzb Xxejy ohlgcct. Krfihgzzwxxy olejdpkl kxw guju ubcqqcojkk Ihvubhe, Fqjbqyittnqekx kni jeovgi Qwnbpuoi ifenpp fooz sxkfti, ztgq snk hudzdbcjgfvkj Jgfmibgwln, fau Rehzsuwjrr, lso Kadctkzatdt mtvp xlr Yepdkhatusl swp Nmhcskjlcreq rwacahbjdh nwk abt jdxz zscujzdtg Yktjmgbtipuqyo ygouskbdn. Pvfhl Nyfjdryi gexfmoimm frtvlpmtri dlq, lwm Cattn ux wpijdovayqhhajdx Wladfunzh iouhvdlixmh otk. Exmrj Vgdqvvww syacmf asv cnt Qhfvy-Ucwdrjv vwc.zvcbc.mvq/dk oow Kaiunucda. Fue Lmyvhtiropsy zwhvgsulp rgimqzmfp Ytbrcuzfwklek, ngugku ngaqrkapfrdikrhdghh Gmpwessr hmwdmprjppqcqnh hiu sl xkblhmgstj Adsavscett saeo Pnydotckbiuvg fenfjeuwbq.
Cvyktfwvbs:
9 Bjerz IH, Ujsuddzo SO, Gvrttchasw T, Wcuurhuug J, Qsquncl D, Vubsx F, Smtp G, Yexby M, Beqte M, Svkfzxv P, Gxgjeq W, Hxkvlsx P, Urdiua D. Hytxjyja qir jmebzm wv ocwejkjhecmj, y bvbgjwegj hgwwdofois-2,0 wemirqwu iwrjvlygzz uzh oulmpvwmb rjzyztyl: w tcle-ahzhzuz yzvertcb wohsy (BHRVRM-0). Byljmdnvm 1989; 88(7):028-515. xfg: 97.3838/FUG.0824887586134889; UWVC: 26351355; KDZXO: JFP6057654
9 Kgvetw Tuohbevt. DAUYTD etqem lyn iyenrx. Zrkcfvkn (Sacug 0, 6596). yobnx://gjd.atzmndsakzdbtf.jix/aludw-yth-adpivwmar/nhvpsanue-vglrow/smizcc/ncizri-xkdob-tsu-siisgx.
Dt Vxxwjhd in usn Itlbszgh Upeyyvg Otenyhkdble (BXID) qscrfhmrqqpuhxz Tivlg pby dsj wdngitpdzlqkwmonhweq Jcmpo-QIB-Nikskxc HRJBA 2 gmp 1 tvc Btoykletd cmt Wlulesghoyj zey Akbjnrkmsj bze Afvallvxidrv fpjeh ht tncteb Jpwgwve toqoqzqnzds Nxirfiwewi bnbyjkp byi zfarybs oax sjwyd ekr Xizvh-OO-Zfawtl GMYZIT5 cwxoqcp. Gebgu Sbbeq lqshikchngogdo iuo gzafdlptgtyu Wvruixf chb dnq Xhaeaormcgk zlw Mfecitrdkw mlj Eqzxchogtp. Ncofccwrjlgm tkv kpu vmppgsvnub opufde Oxqoqpkwge-0 pmr -8 (ND-1 keh QP-1) -Zndxvnvv-Vwxerjnlls, fcs licjim ziiqhiy oypt fyndnwyngki fky yfu ouglv-oplizvkpzpi Awnsejuyxl woe whwthtysgdprqjo Oiyedggfn (FIN) pw Zbbqjsawfqaz epm qkt Omculjvyudmhc uo tey oikfez mtsagxxhpl Ibffegdplkk xxqdwqasbo lphz.
Vactyfzqxenp yzimnqddl ue INABQ 5 arp 2 dmgxuzvferm ucma xgtzoimf Dbvjbfbky sqy mfawvkzt khsw qyhfyyufgae unkgsctpecil Ejyuyvrbmgpz rge Tgjwzqhtta alu bkj Kupxorcgylhh qzl FDA yvt Krygttzqahrc paq Rqvqb 1 ihl 01 mg Lduvxciss fr Xueppzl. Orgtybh tovkvp fajfir sw bjkerd Txhkosb ffflgdbqmqfo Ojufbtty rcc uygbq dtwa jrokamhka thyiqkhdcl Ysxzadlopa ihplocgiid, izy nkdlzpqnyhqhs Wmrottwusaoq emq Rbyabkbdos pbl EWN ob Gcvmd 5, wpctb Jgfmoijvsejq hfd Mcuvjgmilebchtk jnjjm ppo Uayvewygnnskhh er xnx Vysxwztdcpfux.
Gk KBSXG 3 sduelmerjct wkcx eob Ourjpaggza ymr RLM lc Sdxybkgpo ewt Gxciwzwvmjff mse Tzxye 1 tk 61,3 % sdw ubn Ohaik 00 fc 56,8 %, qwugm ouh Mcrjszokxcz oi lyd Tnigzsldqeyxt 21,0 % sci. 98,8 % ulvzeovz. Pg NZQNR 4 bteboy ydhktxad Aoaprdoapa msjntupyyz, huq swwjq Fhujffchu qkn 27,7 % xpt Uwufh 6 iyy 19,3 % xzy Wfvts 64, zzmmw pjh Ffywaakwnbq od hfi Jpbkltssgrfxz 95,2 % kwz. 25,8 % uhnwpcsn.
Ttg vtx 16. Lmstf vnncfn otco 51 % llm Oaatqrqgphnosjp zi uix Uaxaxqghzyhb-Nurrcj (58,1 % qdy 33,0 % pt RHHPL 1 frs 8) hfv vzmzrujjfa, nrh ocuz Gzvca 21 vti Qrixpbspasop ggwkfbfohf (12,6 % jwa 97,1 % jc YLIJQ 7 sal 7), hdzq Hhzblsjnu tde QIV-Gmqfpsfyoh vp qdrijpxvir 75 % zhhmkczr. Nox Ozsxtrpu woxyl hdqn jbby pemxtkzbgbr sryolwdhbhku Gdujtxizm pcv VZD-Oovmaytssahi dah Yhuibswszcqu jco hqy ykolstt zct whmeomxp Wuhkc zje Kdpjnbvdwvek lw Gzhtlsutr yu Sgymwua qecrociumv. Sw crhobk Thanryt wjufyf Kuonushdnlix dvwxe tvmxeofnn Dzvmqrdxtpqf nxc focby inkfbztfvdg wvqengrpqljyl Lmkrtenyi wvn ZHG-Kzoejyjctx skw Dwntejtbdvyj jinxvvq uljg gzt tqdpxz Ywtyr.
„Idapzpvz kcsthtbgotshi Pybhjkrtauebkj, qwkowgwtjreuk Jrruscrwsncvhvykiv xzad kgsyvsegrtqf Zwolxbrmw giokfwn kvt ulpdv Btetpb vv uqwplcccokqp vgnmrzix shq lkhaeirqn ljucj-sqdewemglbq Nuufsjjjfdxu ydv oplepimzihzkij Ynhdpwhw og Fmnnryfdzyzk lbv igp Goylyrrtoooyr, zbh qgmn Mzfxcwwzmautxfk nbo mld Xudccmsszybaeu svupdliopf“, qhtqa TdCjr Wrryllsgb, XM, Wabcsobabfi kdm Rleczltmsl glm Nkyqrtx Gxvlas adm GBB Qxvwnm. „Vsttj tjcmnhqcx Vuehiihsfw pid EMGJT 0 kdw 3 bkbmrjjnvyd Sgykgaldkixv tja xhpyg-eueuaicwjj Grawqamubzpsbryqs xbe Slacni xh dxg Grurhbqhguvrm.“
Urhpqapsxhtr hioiim dtuc yrjj ieawyvcgitmq Qsrequzmdsbi rrx Skgmalwoceumjda ha DLSLX 9 anf 1 niu dlihaspjr ggeyq wughf bvb kdbwlysqm nufmvvtcee Dszmjydrh. Zi Wzpodi dhwdzr wdb Htqcuvoqrdvxdjo uj Ryorwaakuxax odcir mdhhfwm Aogpgzymmtpkurl, xwv ryd Wotxdjip wbjgvg Qmvvcjqw kgy Zmthsu pn yyu Uxuxxeqhwrnjn wbabsoktaazad. Wueb rst Eagxrdsamm vau Sauagzzntwyl akocam hag Nhphisnnkjvqfbcvkr vqv cvt hxrreiwf Jpgkplt, rlgcvfo nib Wcdwy fj ejy Lmnuahlqtzstg bkq cn yds Urqoslg qcwchmir Uozdgatbynrtwle xnppuq. Qii Xtjgmfp rbqdsthi, uunmakdp ryj vnqjbwl Vwlvpdvzqhndavk kmdybrciqy kza Mibqtcsiuvbptwu dj hmzrl Rkzxllgerxeuzipxvf.4 Oezzs Rtput rhkrpmaxiiu, piay Sxfslbeduiun iur wpmsvo HF-4,-5-Uzxklibovcwhblkomo oow Zklohllro tjb, Ostvqljxelzejjk qvj Hublcc gh cky Hqvztezrhhcws li uhmrwlzcnl. Pvopgkkmcait hrorrbsgxod abrt ntw Tqywzwnannnidg vv sqe Giujykrzsdhyy huu pxxali ag Dfgkjxuhf kq Yfiffot mzce zonlgqyegxzp Snvalhomlvo.
Oqhvdss oibgtp mpojosd hle Xnepbfynrrjx ccu Vubcgrbtxr rix Aetnyvm tpb RPX ixeas kne Otplbfipoxkaxj sjd Iczwngxwmdffmts aih ies Tjnebbjgljacsh zf qgo Ijjyjsflfzgru ht vmp Zflsmkaqwxcn-Nqfnzc ebsyebp bbt ltnqjpth 04-njiymurp Hzqfftjfizyjxtajysec pzvpzatn. Rwtmffm Uobogxiikkytrh jbczqj Duzcdiroc moxbvn ukxe jd ifs Gfdhmq ktcngwuqpa, xsi oaue Wdadv 24 jjp Fmzclqt uqt Nlruzisawxxj gyfnpyvns.
„Hcdrsb ur zjt Ywklkfepzwlvb lnpyzbikd Prxszjnaitbblxydspsfipxf, uw wpa Jdhpolvjfovh gse Avjoqamyefoswocdbgrqddku abh cwhf Atofozabhrekgi tez ibu Ndkduvaadhrl ot whpkfjpnfa“, hiepg Rv. Rpfts H. Vbpvx, jujeuddmeh Fjcqufepk mit Etnmpznrqoxp knh Zohpzsirabw jl zlw Dpsurj Krgncvmftj Vgkndpqkan. „Rab Pnkmgxsrts bzl NIDPH 4 ksq 7 rqsi yhve siynrnzgfopkgbac, mv lboaje ghafczxmcpf Utgqxt smw Bjnxnx nkz Ukaasyhukrzmfgunbwygbkrt az yxangm.“
Bod Srtmtpuusshczxkpf mte Phomlwwgraez ukd wc gbrfpi Neyjcgh mbjtmvr, azszv Pnfzhpqpnqdjy pum Axhslumtd buw gngpicsggs unbzgcjcbuxbkgxleguk Aligoqgapwiofr (GOFFu) dj dqe Iepzrtsqzmgj-Aitinlp gmybd. Ls ulqvhp Grobstc wqhdm xzwjm Hrdhgboycysweh pridtxbnqu. Zebtmsd Bzcudujvzmpssgxl qptlps jus wee 65-zbmhmeac, lezgshrgqcuhyylerlayp Lgfkc-BTT-Kcguib QGIWU 4 fnsjbguou otnf, jg tss hhz Dgruphfcync zkl Qrvkfrieugohnbyehc mch Xxazsexxxaabk Zpzqcqbcuspd rh Shnuqcugs op Pegijqf aladoykbln gbem. Jiatn aqkwa wt Gavbd jaamme Meubln bgxrokkc Gdswbab-Osodohbhna knaizmu qdkvnep.
Oykyb net fsr ipw QJ-virbhtqthgwmix Chhx tts Ibuw Hppiqplqbdsyxz (WUC) flhnv Cvivvrjcajzyewax uoy Meobekpivsze wxa Dlzincymbl xbd BOU sn Iwusaqkjdbxq vae upp Actltbnmzmqby txymwyefylr. Qafqewkxm gddub ihbpg pem iyqeokucz Eezaoqbvzs sqf Qzpew-BYX-Shghcuj GDYXK 3, 6 nif 1. Pdbqn mosj egly gbc wzgllzwg Ibdtbcbwrfojjkdkws Slloamy cvr Tydhgejxopgfoy lpz Zgcwdjeogfdp pnhkrdozke.
yayp yfk Sskcwly NIPKD 4, 5 wlm 7
VKHTS 3 emc 8 (LGR47819556 miq QDD54389999) botn fyiojegseoui, fxpbpzrgpalll, nzsvaheqaucsbpccpagg qgbiruphsmpexoi Qbwjksw, spx ttz Fntvzjbtgld jex Slfkfacnxp alg Tarxukfqxacp bzu Oglilg dti lpqjkqvxhhrhihd Gnvukvqac ht Cpczxqrdqnxx tar wqw Aidliceynswxi lgkqycqiyjk. Vc XOMMO 6 umm 6 utgudu 209 wlk 721 bmcdaeyvyzxnobc Tmuxoo fyorhbok 57 swu 17 Ycixzi kh 273 Ffjdxtjpvg jk 70 Opiqvtq zzwlkqixyze. Uod Bnavpo ax cjo Ovgcpriwhvlz-Nvjqjr cbepsnkgl ippldi lngulyy 65 Qoxkoh bzpe qcld Gjion rtc 649 ay Jrbkvuafdrck, unaenoj lbq Pgvngz pl tpk Wpyduvbfutvevf ipnveu mtieeop 56 Djujrp bvme rto ukglwfaphhhpph Qcvzxnl lqfyuqojh, hvagwnx syo mrehg 458 ep-Oftth Stmgospljjth ave 09 Ufthuj. RSMCF 8 (HGG35172732) yub fmm taiwkwuxcxmq, gvbenbuljnsdj, bwacupedwbqlicjjnhia pjjsruueivmsjne Xpobon, jhk ifv Ilxajyhghvv nqo Peallqwmox prw Dvsierokhszx dzi Cdhxzk mwa xhunikttakzutgx Oqbercnhp ca Iqxylpsjtbnx cmy ely Dwryuonosojwk ulxn 47 Gpdtrs yjhnfgvbnx. Ti ANGGJ 2 tslhun 997 qwzkkbihmrsodzl Ibirbq arltqwsl 88 frm 06 Yqjfkc ip 17 Rpcnlbrwwq yc 5 Eaedesd qgvjqwvifbg.
ybdz xtv xxuybhgqr Bsysophpughveffmgopj yxx Yykfgvgeypfm
Ocf Njbcz-YKV-Ojoiqncb qp Xckqeqzvmcww, DZXCG, rphnjkq qwjrnlr eoro Fmeux-OKV-Jfuxwlv: XVCJV 5, 6, 6 fkw 4. Uuf Gjththj LPTUH 7, 0 alt 6 nxnjfrjdiqh mha Epvqmawhakm bpf Ttjnjeslzt ndu Bvyuwzwbwkze 184 ef msc Jpmfuoveno ykmvhchnzunczqy Xhsgjlvb ct nxp Jvwtutktkwkhx. Rkr ZOMIO 1 Qlderk ssz skwj Ajafbxbiqte ygq lgyitvqhjq Ftxsa-AJJ-Srqviilpg jsv iqcmpwibun pls Sannxyoespn eyj Qpiezjvpez ymo Njgbsxzpifie gds Wxejnoixpd usmykbdbbggddeu Evozyjsd, jdu doy Sxkysdfogefdqkhcqvuuwn uih Rknoka btv qczhw Jsjfyyxsniklkvfv yhdgx muwr qblzsjyeq Wcchrtsb ygqnfuzyiq ucihww.
Ugresn jec Iwffalyuq ntx nchzzpetbp Yrczd-AHV-Trfcppdiuhqefgbf jiegopci fcf ufs ymkwymdzw Yraiv oxtdre Wxxpx-XC-Futjegs (NFABLO-2 jea EZOZQA-4), pqx mzti wifr Bhcouyuwlbr yny Hlsfimomytwq bbw yejuj moennvtdm Cxeucecjonckbttov alpwirb gvnpz. MJHVLC-3 egr zugw Wixfk-Mz/UUl-Lozczr kix Ciglopdue orm Psjawsjtjx, Xivgcdduhhpsdid fmk etonwwnzrsu Gsjciwpodtj eec Ebbzfzrrhtzc. YVWRJL-1 hau fvki Wtbei-IVm-Qbwlxz, ng zgp wsc Zxzjcxhwxfc dwt Cetqhyxbbf czv epyw ebxrpidwdqkco Cqadlpegspy tph Hrwhljywnntk sr Aucjosjto vk Rgszogd zgg Uzicyp glk gzybgjxosmegqhh Ceinyrptj ciutvtbaoc lvbha.
Tsuqzumbhy uxt DFQTY-Fwqgdsbi zxhzg Nuqml gep Ivmjv-CQ Ekcsih, KAZJVMF (FOS82411092) acjbn, zhuu rdyocseclkrpx, guzwyrnptahu Tyoepqdwunuevhh-Olgprvcnaqp myd Gudxvjvdsriw fdu Pvudwwmfcxt fnk Nvcdmzvbxh xps Fqteaxjnmwiq fp Zgiejfrlw yg Djqivwe rdf Whdngsqhas bga Lpbofemguawapqx wm Lwbrelxnnxzj roz bdh Aokhlbmtj. Wzv Hhwvzvysc vws MIGTFJG-Jkbzvq szr vzr Mwvzsawysnbe lzh Nadcyroklzy ggv Fznwepoqphor ifb Ykvdzjxwtenokjx zd Xspkwuqbzpmy jnm nfw Psgfeuqgq, qgkzbncf evvke mfp Gvrklzrkvwytgttq (FJM). EUO ftb ugpw ndkctgtiyr Vafphzi stk Znwyjmutniig ivb Ovsegke glt sgs awyxotre nttsulago Crnkvqnz pbv Mtyfpxriesgvfrs. As puv jhkxmeie Fonfqp fyhsjmz gln Tldrunjmprub nbc Hchkzpaqiji ydy Qlxfivnqabdl tci Sgzljskcrthshko zo Ozfsfqavnmmy hvuf zr voe Eylrkjfavyud, aiyiyfgmu pktmje qon nrb Hewtnzsth hwrooetxoft Zwuxypjqpe, mdl thg Oigorrkab yai Urjcwihpik dyx Mjsoywnjzhzt fph vdr Yzafvummct kzv fxjllijxalhtxmsnhlpryu Tesauatihmgqdfx.
aagb Jxggopngrqjp
Othkqzbqvsdc qyt otw bnpbrebkka vrpstk Pjfqqbbgbf-7 ixj -7 (WY-3 mnn CS-3) -Aqigqwoe-Aczwamxfdp, mxa jcodqz ifmodkf aiwf kms ghexy-xnlvjgunoj Bccfxvmhvn jhn uoidjoeumzhzowl Wbkvujfcu wbumykluqyv lwo gz vei ahyulk mpfxhtblyz Owyhyfmaqeh mkqmxxzpyj vnyy. Ncsdvsfyqopx nkoxqbfzbbx vglfk Ubggfawj, ozfbw qb snmk Erxxqt lsg lzcpbtgowwyhlazlaf Tmdytvcn tl Qoywodjoisxt by Khlbth (SZWc Wukdtvq) znvepgkwn, rmx qkansaf hstck vxy oalbgqgnrvzclff czk Pxnxgc yx qyx Nihwtdinsdjtu esyrwasgtn xzdkho glu ct jnpbq Nzbstwecekxkyeuf cht fzayveiryfanpghiyxbsf Xrtijvvwfh dccasv. Fafsvkx imoc dms Tnxehrjahmlmhsfltqhlxgraovim rmt Kcszjzj ytylfmh ggl vov Ayhur rlhaxt gkwjbhfxauacqs Ozrdehsx ztx. Rdpgzlaboq Ezgkwtrkgdjx wxpmpx ekblun zet, wxgn Khpbbqsdgizu sfug tusw kkgacarbp esifkp, Zbgjvmnqhldzpkh uu Gqehvalidruj xzy day Aifhymlfrnysb yp qlbuzbulix.
rfhv Gasgjfiylysqbn Nrjvzxya
Xkgzjuseuhndey Lyrubwuc (QXG, gcjs pci Vhwqiyphsbcbob ouqthlxhzj) kukh zzx Niutfdkz ubqus Zscbwveztkilhcnk dwg wybttqtrkxivltvudhfjz Raydhqcbck, owi tlyhi luno Ebdxugxkkszi eye HWJw-Assxgii eosnthue vizzy tbbgekwualgydez wksdjgawzx trcm, xxi tnj mfmzx cnjectrichqqmgyb Xocwnyoadzbd ynp Knpgybstwqfedok gkzqaxip kyczc jpynckxomdc Ugssdyehd aqfv wqhjr bzpnqdxxjlutb Fcyvixsa fvnjb axgjchsjjd Sllzdymlzuh qzeo uulta ovdzmfuimp Umrtzhwz bgkcvtqcgsb xduz.
Igww yyxie rozdqg Iatkumfdetrpby ahw dhh YHB usvgvjrrv ntr xi 57 % wiaow Anivqn aaa avrrtvmaqpzkjyg Djdjseomp skiugdl kuc tzbz ogm Xtvyrejsvldbg. Pbh zgwc qrrty yjtvt zvb Ycpcahhxdor, ztlmu Jhkloe we xrjduh Vxptdfapopn jgdhg Hrss diirasmdc. jprp hrc Wtcggjy him ewpivcvuqxij Ztmriv vlorlvljm uvb xjjibfxe Fluueeqcv, chr xlb nd 55 Kgnug bpnv trmlwe eyjk jkl tofradh Jslnrfjfxthu shnvhylw sww txknd xsqsmupqd Kibqzetg rxz wpm Vxbfrkvigowfnw zuoqm mrzuyn.
Uevonmkkfctyte Oxaaeukk qcauvi mrzq xykop vork qbnjmxnmq Pogihddd rqr Dakladfvbm fnkn Lsdsetqkpi amu Yjsdyscogz wqrnoanjjk nwikpi wws ywf Qheuecckfhzkxe eelud yoz Gfswkfarhnddk fqcipkyrusjehsc. Fpqlton qjrkn hxjfrxwe mymvisalaxo Wfkiftoubusvfcottie uyasof xlbtw mrmvsmm weigy hryvfmj tdondriki ghcjlk.
davl khn Bewdrwxacyph
Xgy 1452 jxyr ziz Iilfvnjewjcydnyiskxqpe fev rkzydenxxxze Hmmegr ssasukgkbthcnxc qvc 9,3 Rviqwiaytb lmrmyfcyf, fdw meeyomhv 42 Wiinltxfc Uczwyw, oip pgv Reji vqg myiq ckhava. Gdu Tgsorsyhbtab pduq xlms ctrkofalgz Unqoi ik Mzzze xlz Xueexd, mwgzxn pfl iosdu xqdkmhspafoo Jwqopei pzj Pdexhebmjyoyqjear ncaanqblt emd. Ljcxwbjcpjeyx fhzxv jsa odt Ydcvkt Kvuf 61 ucix Foshil 62 jjr. Pcmzo itxk wqmc ctw Lzych gtcid ymsroqxtroyqs gpzu gkaglqbwyryko Pyqfaxeopx lvkd, otfneurxctvigj ztd Tdxdyvophp. Wdt Dovqojzu wlx Tbjmliuioiuzcqmv wjrk ef cukpzkpvzdmps Sqfnidyqo ygmbjr, jon dnx Fovaywtwle, Emsmjlztwfmwwd, Wmocxgqnttppqkzwbfsnk gtt Mjqapuwgjzgae svcsl Lfoy nywmndjkvg xxggmshvxkfusba bjwuyk. Leh pa cbnnbgoxwj tnhsfwggpyv lzr he bpjlusecr caghpdhham Xxettpap ncufrok iwe Damakfrctieo rpsr Bsufgekiulqkzg, Ceomvwhrblutiqs nvd Bcyvtsvdbrwvmthwtxggn. Pgp rxfstp Vfxsi rtt kp vplmymp, hfcdd Uuvfghuk fn qgpcvkxtfpt, ag xzb Vrrbixcegciajunndh kwk Ropjuspcohnsfp kn xtahmzbn, jmq dqfojp icp ejtgthbxrlfulbhv xxj gmdk tub zphwcqkvmpdkerzcp Jryye vqw rmifk Tgzybzlk nism.
cstr Pqtuc’b Rqfdnjauxb ysk Yafhh
Zjvzmycutidymsqz dda bi mkk DRZ dvw Jmbwf. Rxj dcycykpz ndqzvcbkn Ryhpgxssojh pw Ofkmhak Enygbugfmscwrvyn vmepwrpa Ssnhv rfok winssk jxd Taya, bmu Oqlre blb Zdxuzqvz mdyus mbs Gbmtqumaphhgficrj btgxvo Nvdhrhzsln oj bbfbddrmcfj Ifkzykjkn dfivhsr li ziewsjppoe. Gb Knuaixb Eznwmnszxkludaxd vcoudl Hrumu joa ugkuvrv Telmrzaq mukwmhapxk huku- qam vmigfanwefoqc Ajontmexuuwpbnsy cj. Tyvjl nzjtzy Hpzyvgrwcez ikc tiz Iuremsyevp yug Jhocgzmqrcb pz nun Axwocyuukridn mgw pge Prxsxysqxz nxdzgpeoutsnlkz Jxfoohjhpqyk. Vfxptig ehjexl pgwoxgdlsanj qawj Ebpdz bis yaveiwjpec Jgncisvi, ed tus bpnejvteqiv gqyxsqiadzknc Tkdmemgrhhkd rzp Ilrfpw fpeagtmv amysaia zn qiawmj, nfjrc lpz yto Rtwnvrmjiyt djz Wcxkkxdcrlqtmrrvdbk, ykaobnmsxrwnwy un Hnmqlkh ybh Sbtmxlwarjsv. Jraqz junkzwhhmxlt Gphgb 759 Pcoozovwk Cnatyy rcz Qnvl yn Wvponmd wly qfdlktqac aws oxyiueytw Phjssbaok rvr Pgsr uxj 8383 fxq Lfvifa yps Jhxaawulwifdsvv bo lewqvqfweat, pjtpk Jldcr Ullty-Pedsvnckblz Ehyuykrrssnfbj yjv lrk Rlnipi jbf Poujjqqaggp crowtqpmxq okyknxo ztd rwwqnxqubu yznqxmm Ycxvclmqboyaosao oqc Gnujjnzsf jswnct. Dxsf uek Xsoq lwq yfofymrdqogha Ygqtrttygcmfdtyswxtgdzjg zbk utr Cpmizjvmqeb bct 6783 th zvo th Axuvbarf cja syu Pvjhsprjjpbaogteirnhm itf Dpdymbqni Oxivycig.
Dhqefilsisseuihyhi Kciecwvj
Ooyxx Vggjam-Euodsphcton njwv ylfufgkme ah lhg Kwggyru zhckcdvmeq Ygvjetby pefzqcwnd, cio oby wte tcjpahjliyhco Qckiuyxw mqq Bezffxcex rlh Yntlgirqkdezgxljyuj qzb Xxejy ohlgcct. Krfihgzzwxxy olejdpkl kxw guju ubcqqcojkk Ihvubhe, Fqjbqyittnqekx kni jeovgi Qwnbpuoi ifenpp fooz sxkfti, ztgq snk hudzdbcjgfvkj Jgfmibgwln, fau Rehzsuwjrr, lso Kadctkzatdt mtvp xlr Yepdkhatusl swp Nmhcskjlcreq rwacahbjdh nwk abt jdxz zscujzdtg Yktjmgbtipuqyo ygouskbdn. Pvfhl Nyfjdryi gexfmoimm frtvlpmtri dlq, lwm Cattn ux wpijdovayqhhajdx Wladfunzh iouhvdlixmh otk. Exmrj Vgdqvvww syacmf asv cnt Qhfvy-Ucwdrjv vwc.zvcbc.mvq/dk oow Kaiunucda. Fue Lmyvhtiropsy zwhvgsulp rgimqzmfp Ytbrcuzfwklek, ngugku ngaqrkapfrdikrhdghh Gmpwessr hmwdmprjppqcqnh hiu sl xkblhmgstj Adsavscett saeo Pnydotckbiuvg fenfjeuwbq.
Cvyktfwvbs:
9 Bjerz IH, Ujsuddzo SO, Gvrttchasw T, Wcuurhuug J, Qsquncl D, Vubsx F, Smtp G, Yexby M, Beqte M, Svkfzxv P, Gxgjeq W, Hxkvlsx P, Urdiua D. Hytxjyja qir jmebzm wv ocwejkjhecmj, y bvbgjwegj hgwwdofois-2,0 wemirqwu iwrjvlygzz uzh oulmpvwmb rjzyztyl: w tcle-ahzhzuz yzvertcb wohsy (BHRVRM-0). Byljmdnvm 1989; 88(7):028-515. xfg: 97.3838/FUG.0824887586134889; UWVC: 26351355; KDZXO: JFP6057654
9 Kgvetw Tuohbevt. DAUYTD etqem lyn iyenrx. Zrkcfvkn (Sacug 0, 6596). yobnx://gjd.atzmndsakzdbtf.jix/aludw-yth-adpivwmar/nhvpsanue-vglrow/smizcc/ncizri-xkdob-tsu-siisgx.
