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Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 69120 Heidelberg, Germany http://www.dkfz.de
Contact Ms Dr. Sibylle Kohlstädt +49 6221 422854
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Deutsches Krebsforschungszentrum

Aktivierte Immunzellen signalisieren günstige Prognose bei Darmkrebs

(PresseBox) (Heidelberg, )
Aktivierte zytotoxische T-Zellen ("Killerzellen") produzieren den Immunbotenstoff Tumornekrosefaktor alpha. Wissenschaftler aus dem Deutschen Krebsforschungszentrum und aus den Universitätskliniken Heidelberg und Dresden wiesen nun nach, dass mit steigender Konzentration von TNF alpha im Tumorgewebe die Anzahl an aktivierten Killerzellen steigt, die den Tumor spezifisch erkennen und bekämpfen können. Hohe TNF alpha-Spiegel im Tumor erwiesen sich als unabhängiger prognostischer Marker für einen günstigen Verlauf der Krebserkrankung.

Seit einigen Jahren bereits wird nach Darmkrebsoperationen das Tumorgewebe auf eingewanderte Immunzellen untersucht. Findet der Pathologe viele der als "Killerzellen" bezeichneten zytotoxischen T-Zellen, so ist ein günstiger Verlauf der Erkrankung wahrscheinlich und das Risiko für Metastasen zikpsuob.

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