A new EMBL study reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins. The results of the study, published in The EMBO Journal, could potentially help in the development of drugs against certain chemotherapy- and radiotherapy-resistant cancers. Summary
The protein MAGEA4 contributes to cancer survival by preventing the degradation of a cancer-promoting protein called RAD18, which is implicated in resistance to certain kinds of chemotherapy and radiotherapy.
Researchers from the Bhogaraju group at EMBL Grenoble have studied the structure of the MAGEA4-RAD18 complex and identified a hotspot
The protein MAGEA4 contributes to cancer survival by preventing the degradation of a cancer-promoting protein called RAD18, which is implicated in resistance to certain kinds of chemotherapy and radiotherapy.
Researchers from the Bhogaraju group at EMBL Grenoble have studied the structure of the MAGEA4-RAD18 complex and identified a hotspot
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