Der Abbau von Eiweißen (Proteinen) in Zellen ist lebenswichtig. Ist er gestört, können schwere Erkrankungen die Folge sein. Jetzt hat die Forschergruppe von Prof. Thomas Jentsch (Max-Delbrück-Centrum für Molekulare Medizin, MDC, Berlin-Buch/Leibniz-Institut für Molekulare Pharmakologie, FMP) einen dafür grundlegenden zellbiologischen Vorgang aufgeklärt. In gleich zwei Publikationen, die jetzt die amerikanische Fachzeitschrift Science veröffentlicht hat, konnten sie zeigen, dass der Proteinabbau in winzigen Zellorganellen entgegen gängiger Lehrmeinung nicht allein vom pH-Wert abhängt, sondern von der Anreicherung von Chloridionen in ihrem Innern (Science Express online DOI: 10.1126/science.1188070; DOI: 10.1126/science.1188072)*.
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