More and more studies show that a disbalance in the gut-microbiome can negatively impact patients suffering from various neurodegenerative diseases such as Alzheimer’s disease by contributing to disease progression. To study Alzheimer’s disease, Dunn Labortechnik offers antibodies against Amyloid-beta and Tau. But how does our brain know about the millions of microbes in our gut?
The microorganisms in our intestine influence communication between gut and brain by producing various metabolites such as short-chain fatty acids which can be sensed by a specialized group of enteroendocrine cells. This subgroup of enteroendocrine cells directly communicates with the vagus nerve, a main component of the parasympathetic nervous system, conveying signals directly to the central nervous system. Apart from enteroendocrine cells, sensory neurons connecting to enteric motor neurons and vagus nerve fibers, also express receptors for many microbial metabolites and other microbial components.
Our immune system preservers tolerance towards a multitude of beneficial microbial strains, while surveying the gut for potential pathological strains. Immune cells thereby contribute to the crosstalk between the microbiota and the brain and influence the production and release of various neurotransmitters and cytokines.
Alzheimer’s disease is one of the most common, age-related neurological diseases in elderly humans and characterized by amyloid-beta plaque formation as well as tau-containing neurofibrillary tangles. Studies analysing the microbiome in Alzheimer patients found significant differences between patients and age-matched controls, for example: while Firmicutes and Bifidobacterium are decreased in patients with Alzheimer’s, Bacteroidetes and Proteobacteria are increased. Further, several studies on Alzheimer mouse models showed a significant reduction of amyloid plaques after transplantation of healthy fecal microbiota. Exchanging the “disbalanced” microbiome subsequently changed the gut metabolome and local cytokine expression, which in return influenced gut-brain communication, improving pathological features in the brain.
For a systematic view on Alzheimer’s disease, Dunn Labortechnik provides a vast selection of various immunoreagents from well-known suppliers such as Innovative Research, Meridian Bioscience, Immunology Consultants Laboratory (ICL) and Icon Medlab. Their portfolio covers human plasma and serum samples from normal donors as well as Alzheimer’s patients, recombinant proteins, ELISA kits and more. You already have the perfect antibody, but you need it conjugated to HRP or AP? Try conjugating the antibody yourself with labelling kits by MOSS.
The microorganisms in our intestine influence communication between gut and brain by producing various metabolites such as short-chain fatty acids which can be sensed by a specialized group of enteroendocrine cells. This subgroup of enteroendocrine cells directly communicates with the vagus nerve, a main component of the parasympathetic nervous system, conveying signals directly to the central nervous system. Apart from enteroendocrine cells, sensory neurons connecting to enteric motor neurons and vagus nerve fibers, also express receptors for many microbial metabolites and other microbial components.
Our immune system preservers tolerance towards a multitude of beneficial microbial strains, while surveying the gut for potential pathological strains. Immune cells thereby contribute to the crosstalk between the microbiota and the brain and influence the production and release of various neurotransmitters and cytokines.
Alzheimer’s disease is one of the most common, age-related neurological diseases in elderly humans and characterized by amyloid-beta plaque formation as well as tau-containing neurofibrillary tangles. Studies analysing the microbiome in Alzheimer patients found significant differences between patients and age-matched controls, for example: while Firmicutes and Bifidobacterium are decreased in patients with Alzheimer’s, Bacteroidetes and Proteobacteria are increased. Further, several studies on Alzheimer mouse models showed a significant reduction of amyloid plaques after transplantation of healthy fecal microbiota. Exchanging the “disbalanced” microbiome subsequently changed the gut metabolome and local cytokine expression, which in return influenced gut-brain communication, improving pathological features in the brain.
For a systematic view on Alzheimer’s disease, Dunn Labortechnik provides a vast selection of various immunoreagents from well-known suppliers such as Innovative Research, Meridian Bioscience, Immunology Consultants Laboratory (ICL) and Icon Medlab. Their portfolio covers human plasma and serum samples from normal donors as well as Alzheimer’s patients, recombinant proteins, ELISA kits and more. You already have the perfect antibody, but you need it conjugated to HRP or AP? Try conjugating the antibody yourself with labelling kits by MOSS.
